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Critical Care Medicine

Clinical Outcomes in Young US Adults Hospitalized With COVID-19

Educational Objective
To understand the clinical outcomes in young US adults hospitalized with COVID-19

1 Credit CME

JAMA Internal Medicine

Published Online: September 9, 2020

Research Letter

Article Information and Disclosures

Jonathan W. Cunningham, MD¹;

Muthiah Vaduganathan, MD, MPH¹;

Brian L. Claggett, PhD¹;

Karola S. Jering, MD¹;

Ankeet S. Bhatt, MD, MBA¹;

Ning Rosenthal, MD, MPH, PhD²;

Scott D. Solomon, MD¹

Author Affiliations

¹Brigham and Women’s Hospital, Boston, Massachusetts
²Premier Applied Sciences, Premier Inc, Charlotte, North Carolina

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Article Information

Accepted for Publication: August 14, 2020.

Corresponding Author: Scott D. Solomon, MD, Cardiovascular Division, Brigham and Women’s Hospital, 75 Francis St, Boston, MA 02115 (ssolomon@bwh.harvard.edu).

Published Online: September 9, 2020. doi:10.1001/jamainternmed.2020.5313

Author Contributions: Dr Solomon had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Drs Cunningham and Vaduganathan contributed equally as co–first authors.

Concept and design: Cunningham, Jering, Bhatt, Solomon.

Acquisition, analysis, or interpretation of data: Cunningham, Vaduganathan, Claggett, Jering, Rosenthal, Solomon.

Drafting of the manuscript: Cunningham, Vaduganathan.

Critical revision of the manuscript for important intellectual content: All authors.

Statistical analysis: Cunningham, Claggett, Jering, Rosenthal, Solomon.

Obtained funding: Solomon.

Administrative, technical, or material support: Jering.

Supervision: Solomon.

Conflict of Interest Disclosures: Dr Cunningham reported grants from the National Heart, Lung, and Blood Institute (T32HL094301) during the conduct of the study. Dr Vaduganathan reported grants from Harvard Catalyst, grants and personal fees from Amgen, and personal fees from AstraZeneca, Baxter HealthCare, Bayer AG, Boehringer Ingelheim, Cytokinetics, and Relypsa outside the submitted work. Dr Claggett reported personal fees from Amgen, Boehringer Ingelheim, Corvia, MyoKardia, and Novartis outside the submitted work. Dr Rosenthal is an employee of Premier Inc, which curates the Premier Healthcare Database. Dr Bhatt reported speaking fees from Sanofi Pasteur and is supported by the Heart, Lung, and Blood Institute T32 postdoctoral training grant T32HL007604. Dr Solomon reported grants from Alnylam, Amgen, AstraZeneca, Bellerophon, Bayer, BMS, Celladon, Cytokinetics, Eidos, Gilead, GSK, Ionis, Lone Star Heart, Mesoblast, MyoKardia, Neurotronik, National Institutes of Health/National Heart, Lung, and Blood Institute, Novartis, Respicardia, Sanofi Pasteur, Theracos and personal fees from Akros, Alnylam, Amgen, Arena, AstraZeneca, Bayer, BMS, Cardior, Cardurion, Corvia, Cytokinetics, Daiichi-Sankyo, Gilead, GSK, Ironwood, Merck, Myokardia, Novartis, Roche, Takeda, Theracos, Quantum Genetics, Cardurion, AoBiome, Janssen, Cardiac Dimensions, Sanofi-Pasteur, Tenaya, Dinaqor, Tremeau, CellProThera, and Moderna outside the submitted work. No other disclosures were reported.

References

COVID-NET. COVID-19–associated hospitalization surveillance network, Centers for Disease Control and Prevention. Accessed July 21, 2020. https://gis.cdc.gov/grasp/covidnet/COVID19_3.html

Premier Applied Sciences. Premier Healthcare Database: data that informs and performs. Accessed August 7, 2020. https://learn.premierinc.com/white-papers/premier-healthcare-database-whitepaper

Vail E , Gershengorn HB , Hua M , Walkey AJ , Rubenfeld G , Wunsch H . Association between US norepinephrine shortage and mortality among patients with septic shock. JAMA. 2017;317(14):1433-1442. doi:10.1001/jama.2017.2841 PubMed Google Scholar Crossref

Yang J , Biery DW , Singh A , et al. Risk factors and outcomes of very young adults who experience myocardial infarction: the Partners YOUNG-MI Registry. Am J Med. 2020;133(5):605-612.e1. doi:10.1016/j.amjmed.2019.10.020 PubMed Google Scholar Crossref

Martinez DA , Hinson JS , Klein EY , et al. SARS-CoV-2 positivity rate for Latinos in the Baltimore-Washington, DC region. JAMA. 2020. doi:10.1001/jama.2020.11374 PubMed Google Scholar

Price-Haywood EG , Burton J , Fort D , Seoane L . Hospitalization and mortality among Black patients and White patients with Covid-19. N Engl J Med. 2020;382(26):2534-2543. doi:10.1056/NEJMsa2011686 PubMed Google Scholar Crossref

AMA CME Accreditation Information

Credit Designation Statement: The American Medical Association designates this Journal-based CME activity activity for a maximum of 1.00  AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to:

1.00 Medical Knowledge MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program;;
1.00 Self-Assessment points in the American Board of Otolaryngology – Head and Neck Surgery’s (ABOHNS) Continuing Certification program;
1.00 MOC points in the American Board of Pediatrics’ (ABP) Maintenance of Certification (MOC) program;
1.00 Lifelong Learning points in the American Board of Pathology’s (ABPath) Continuing Certification program; and
1.00 CME points in the American Board of Surgery’s (ABS) Continuing Certification program

It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting MOC credit.