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Clinical Outcomes in Young US Adults Hospitalized With COVID-19

Educational Objective
To understand the clinical outcomes in young US adults hospitalized with COVID-19

Coronavirus disease 2019 (COVID-19) is increasing rapidly among young adults in the US.1 Often described as a disease affecting older adults, to our knowledge, few studies have included younger patients to better understand their anticipated clinical trajectory. We investigated the clinical profile and outcomes of 3222 young adults (defined by the US Census as age 18-34 years) who required hospitalization for COVID-19 in the US.

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Article Information

Accepted for Publication: August 14, 2020.

Corresponding Author: Scott D. Solomon, MD, Cardiovascular Division, Brigham and Women’s Hospital, 75 Francis St, Boston, MA 02115 (ssolomon@bwh.harvard.edu).

Published Online: September 9, 2020. doi:10.1001/jamainternmed.2020.5313

Author Contributions: Dr Solomon had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Drs Cunningham and Vaduganathan contributed equally as co–first authors.

Concept and design: Cunningham, Jering, Bhatt, Solomon.

Acquisition, analysis, or interpretation of data: Cunningham, Vaduganathan, Claggett, Jering, Rosenthal, Solomon.

Drafting of the manuscript: Cunningham, Vaduganathan.

Critical revision of the manuscript for important intellectual content: All authors.

Statistical analysis: Cunningham, Claggett, Jering, Rosenthal, Solomon.

Obtained funding: Solomon.

Administrative, technical, or material support: Jering.

Supervision: Solomon.

Conflict of Interest Disclosures: Dr Cunningham reported grants from the National Heart, Lung, and Blood Institute (T32HL094301) during the conduct of the study. Dr Vaduganathan reported grants from Harvard Catalyst, grants and personal fees from Amgen, and personal fees from AstraZeneca, Baxter HealthCare, Bayer AG, Boehringer Ingelheim, Cytokinetics, and Relypsa outside the submitted work. Dr Claggett reported personal fees from Amgen, Boehringer Ingelheim, Corvia, MyoKardia, and Novartis outside the submitted work. Dr Rosenthal is an employee of Premier Inc, which curates the Premier Healthcare Database. Dr Bhatt reported speaking fees from Sanofi Pasteur and is supported by the Heart, Lung, and Blood Institute T32 postdoctoral training grant T32HL007604. Dr Solomon reported grants from Alnylam, Amgen, AstraZeneca, Bellerophon, Bayer, BMS, Celladon, Cytokinetics, Eidos, Gilead, GSK, Ionis, Lone Star Heart, Mesoblast, MyoKardia, Neurotronik, National Institutes of Health/National Heart, Lung, and Blood Institute, Novartis, Respicardia, Sanofi Pasteur, Theracos and personal fees from Akros, Alnylam, Amgen, Arena, AstraZeneca, Bayer, BMS, Cardior, Cardurion, Corvia, Cytokinetics, Daiichi-Sankyo, Gilead, GSK, Ironwood, Merck, Myokardia, Novartis, Roche, Takeda, Theracos, Quantum Genetics, Cardurion, AoBiome, Janssen, Cardiac Dimensions, Sanofi-Pasteur, Tenaya, Dinaqor, Tremeau, CellProThera, and Moderna outside the submitted work. No other disclosures were reported.

References
1.
COVID-NET. COVID-19–associated hospitalization surveillance network, Centers for Disease Control and Prevention. Accessed July 21, 2020. https://gis.cdc.gov/grasp/covidnet/COVID19_3.html
2.
Premier Applied Sciences. Premier Healthcare Database: data that informs and performs. Accessed August 7, 2020. https://learn.premierinc.com/white-papers/premier-healthcare-database-whitepaper
3.
Vail  E , Gershengorn  HB , Hua  M , Walkey  AJ , Rubenfeld  G , Wunsch  H .  Association between US norepinephrine shortage and mortality among patients with septic shock.   JAMA. 2017;317(14):1433-1442. doi:10.1001/jama.2017.2841PubMedGoogle ScholarCrossref
4.
Yang  J , Biery  DW , Singh  A ,  et al.  Risk factors and outcomes of very young adults who experience myocardial infarction: the Partners YOUNG-MI Registry.   Am J Med. 2020;133(5):605-612.e1. doi:10.1016/j.amjmed.2019.10.020PubMedGoogle ScholarCrossref
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Martinez  DA , Hinson  JS , Klein  EY ,  et al.  SARS-CoV-2 positivity rate for Latinos in the Baltimore-Washington, DC region.   JAMA. 2020. doi:10.1001/jama.2020.11374PubMedGoogle Scholar
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Price-Haywood  EG , Burton  J , Fort  D , Seoane  L .  Hospitalization and mortality among Black patients and White patients with Covid-19.   N Engl J Med. 2020;382(26):2534-2543. doi:10.1056/NEJMsa2011686PubMedGoogle ScholarCrossref
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