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COVID-19 and the Path to Immunity

Educational Objective
To understand how B-cell and T-cell mediated adaptive immunity to COVID-19 can help us manage the pandemic
1 Credit CME

The emergence of adaptive immunity in response to the novel Betacoronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), occurs within the first 7 to 10 days of infection.13 Understanding the key features and evolution of B-cell– and T-cell–mediated adaptive immunity to SARS-CoV-2 is essential in forecasting coronavirus disease 2019 (COVID-19) outcomes and for developing effective strategies to control the pandemic. Ascertaining long-term B-cell and T-cell immunological memory against SARS-CoV-2 is also critical to understanding durable protection.

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Article Information

Corresponding Author: David S. Stephens, MD, Emory University School of Medicine, Robert W. Woodruff Health Sciences Center, Emory University, 1440 Clifton Rd NE, #420, Atlanta, GA 30322 (dstep01@emory.edu).

Published Online: September 11, 2020. doi:10.1001/jama.2020.16656

Conflict of Interest Disclosures: Drs Stephens and McElrath reported that they are supported by awards UM1AI148684 (Emory University) and UM1AI068618 (Fred Hutchinson Cancer Research Center) from the National Institute of Allergy and Infectious Disease (NIAID) and are members of the NIAID Infectious Diseases Clinical Research Consortium–Vaccine and Treatment Evaluation Units, and COVID Prevention Networks. Dr McElrath reported that she is a member of the HIV Vaccine Trials Network.

Disclaimer: The conclusions in this report are those of the authors and do not necessarily represent views of the respective institutions or the National Institutes of Health.

Additional Contributions: We thank Rafi Ahmed, PhD, for reviewing the manuscript and Michael Konomos, MS, CMI, for illustration input, for which neither was compensated.

References
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