JAMA Health Forum launched on January 23, 2020—just 3 days after the first person tested positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the US and 1 week before the World Health Organization (WHO) declared coronavirus disease 2019 (COVID-19) a “global public health emergency.”1 The timing of this launch was coincidental, yet it provided an urgent opportunity for JAMA Health Forum to pivot rapidly to identify and publish leading-edge content as the COVID-19 threat became more clear. Seven weeks later, the WHO declared COVID-19 a global pandemic as rapidly increasing numbers of cases were diagnosed across 6 continents. Over the ensuing 6 months, the global pandemic has become the greatest public health crisis and challenge to health care systems of the past century, causing nearly 1 million deaths worldwide and nearly 200 000 deaths in the US.