Accepted for Publication: August 17, 2020.
Published: September 23, 2020. doi:10.1001/jamanetworkopen.2020.22058
Open Access: This is an open access article distributed under the terms of the CC-BY License. © 2020 Foy BH et al. JAMA Network Open.
Corresponding Authors: John M. Higgins, MD (firstname.lastname@example.org), and Jonathan C. T. Carlson, MD, PhD (email@example.com), Simches Research Center, 185 Cambridge St, Boston, MA 02114.
Author Contributions: Dr Higgins had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Concept and design: Foy, Carlson, Westover, Aguirre, Higgins.
Acquisition, analysis, or interpretation of data: All authors.
Drafting of the manuscript: Foy, Reinertsen, Mow, Higgins.
Critical revision of the manuscript for important intellectual content: Foy, Carlson, Reinertsen, Padros I Valls, Pallares Lopez, Palanques-Tost, Westover, Aguirre, Higgins.
Statistical analysis: Foy, Higgins.
Obtained funding: Higgins.
Administrative, technical, or material support: Reinertsen, Mow, Aguirre, Higgins.
Supervision: Carlson, Westover, Aguirre, Higgins.
Conflict of Interest Disclosures: Dr Westover reported grants from the National Institutes of Health during the conduct of the study. Dr Aguirre reported grants from the CRICO Risk Management Foundation during the conduct of the study. Dr Higgins reported grants from the One Brave Idea Initiative and grants from Fast Grants at the Mercatus Center, George Mason University during the conduct of the study. No other disclosures were reported.
Funding/Support: This work was supported by grants from the One Brave Idea Initiative and from Fast Grants at the Mercatus Center, George Mason University (Dr Higgins); grants from the CRICO Risk Management Foundation (Drs Westover and Aguirre); the Glenn Foundation for Medical Research and American Federation for Aging Research Breakthroughs in Gerontology Grant (Dr Westover); the American Academy of Sleep Medicine Foundation Strategic Research Award (Dr Westover), the Football Players Health Study grant at Harvard University (Dr Westover); a subcontract from Moberg ICU Solutions, Inc through the US Department of Defense (Dr Westover); and the following NIH grants: 1R01NS102190, 1R01NS102574, 1R01NS107291, and 1RF1AG064312 (Dr Westover).
Role of the Funder/Sponsor: The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
G , Zangrillo
A , Zanella
et al; COVID-19 Lombardy ICU Network. Baseline characteristics and outcomes of 1591 patients infected with SARS-CoV-2 admitted to ICUs of the Lombardy region, Italy. JAMA
. 2020;323(16):1574-1581. doi:10.1001/jama.2020.5394
HH , Patel
HR , Higgins
JM . Modulation of red blood cell population dynamics is a fundamental homeostatic response to disease. Am J Hematol
. 2015;90(5):422-428. doi:10.1002/ajh.23982
JL , Ronnow
BS , Horne
et al; Intermountain Heart Collaborative (IHC) Study Group. Usefulness of a complete blood count-derived risk score to predict incident mortality in patients with suspected cardiovascular disease. Am J Cardiol
. 2007;99(2):169-174. doi:10.1016/j.amjcard.2006.08.015
GM , Allen
LA , Pocock
et al; CHARM Investigators. Red cell distribution width as a novel prognostic marker in heart failure: data from the CHARM Program and the Duke Databank. J Am Coll Cardiol
. 2007;50(1):40-47. doi:10.1016/j.jacc.2007.02.067
E , Ulcay
A , Tanoglu
et al. Clinical usefulness of mean platelet volume and red blood cell distribution width to platelet ratio for predicting the severity of hepatic fibrosis in chronic hepatitis B virus patients. Eur J Gastroenterol Hepatol
. 2014;26(12):1320-1324. doi:10.1097/MEG.0000000000000203
KV , Semba
RD , Ferrucci
et al. Red cell distribution width and mortality in older adults: a meta-analysis. J Gerontol A Biol Sci Med Sci
. 2010;65(3):258-265. doi:10.1093/gerona/glp163
A , Miller
GD , Eichner
D , Higgins
JM . Single-cell modeling of routine clinical blood tests reveals transient dynamics of human response to blood loss. Elife
. 2019;8:e48590. doi:10.7554/eLife.48590
JB , Lappe
DL , Anderson
et al. Both initial red cell distribution width (RDW) and change in RDW during heart failure hospitalization are associated with length of hospital stay and 30-day outcomes. Int J Lab Hematol
. 2016;38(3):328-337. doi:10.1111/ijlh.12490PubMedGoogle Scholar
EK , Zambrano
LD , Anderson
et al. Coronavirus disease 2019 case surveillance—United States, January 22-May 30, 2020. MMWR Morb Mortal Wkly Rep
. 2020;69(24):759-765. doi:10.15585/mmwr.mm6924e2PubMedGoogle Scholar
EG , Burton
J , Fort
D , Seoane
L . Hospitalization and mortality among black patients and white patients with COVID-19. N Engl J Med
. 2020;382(26):2534-2543. doi:10.1056/NEJMsa2011686
J , Goldmann
DA , McGowan
Jr . Methodologic issues in hospital epidemiology. IV. Risk ratios, confounding, effect modification, and the analysis of multiple variables. Rev Infect Dis
. 1988;10(6):1118-1141. doi:10.1093/clinids/10.6.1118
Y , Ye
G , Zeng
et al. Can routine laboratory tests discriminate SARS-CoV-2-infected pneumonia from other causes of community-acquired pneumonia? Clin Transl Med
. 2020;10(1):161-168. doi:10.1002/ctm2.23
Y , Weinberg
SE , Zhao
et al. Risk stratification of hospitalized COVID-19 patients through comparative studies of laboratory results with influenza. EClinicalMedicine
. Published online July 30, 2020. doi:10.1016/j.eclinm.2020.100475
C , Deng
R , Gou
et al. Preliminary study to identify severe from moderate cases of COVID-19 using combined hematology parameters. Ann Transl Med
. 2020;8(9):593. doi:10.21037/atm-20-3391
J , Ou
J , Qiu
et al. A tool to early prediction of severe corona virus disease 2019 (COVID-19): a multicenter study using the risk nomogram in Wuhan and Guangdong, China. Clin Infect Dis
. 2020;71(15):833-840. doi:10.1093/cid/ciaa443
A , Somani
S , Russak
et al. Machine learning to predict mortality and critical events in COVID-19 positive New York City patients. medRxiv. Preprint posted online April 28, 2020. doi:10.1101/2020.04.26.20073411
L , Boscolo
A , Poletto
et al. COVID-19-related severe hypercoagulability in patients admitted to intensive care unit for acute respiratory failure. Thromb Haemost
. 2020;120(6):998-1000. doi:10.1055/s-0040-1710018