The coronavirus disease 2019 (COVID-19) pandemic increasingly weighs on the US psyche as it exposes structural inequities, intensifies long-standing mental health access challenges, and vastly increases the number of individuals in need of treatment. Neuropsychiatric sequelae1 have developed in some survivors after COVID-19 infection, whereas others have been traumatized in their roles as frontline health care workers and first responders. Still others have been stricken with new anxiety or depressive disorders, while those with preexisting mental health problems have seen their conditions worsen amid social distancing directives. As demands on our already strained and specialty-focused mental health care system increase, one of the most promising solutions for the pandemic’s unique needs is expediting the integration of mental and physical health care in the primary care setting, with the collaborative care model (CoCM) being an extensively evidence-based strategy.