Kreps and colleagues’ survey1 of a national sample of US adults provides insights into how we might achieve the level of vaccine uptake needed to prevent the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This study lands at a critical moment for US public health. The SARS-CoV-2 pandemic is surging, influenza season is looming, and the delivery of a vaccine to protect against coronavirus disease 2019 (COVID-19), the disease caused by SARS-CoV-2, appears imminent through the US government’s Operation Warp Speed initiative.