Accepted for Publication: August 4, 2020.
Corresponding Author: Matthew J. Schipper, PhD, Department of Radiation Oncology, University of Michigan, 1415 Washington Heights, Ann Arbor, MI 48109 (mjschipp@umich.edu).
Published Online: October 29, 2020. doi:10.1001/jamaoncol.2020.5403
Author Contributions: Ms Hartman and Dr Schipper had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. Drs Schipper and Spratt contributed equally.
Concept and design: Hartman, Dess, Jackson, Morris, Li, Zaorsky, Schipper, Spratt.
Acquisition, analysis, or interpretation of data: Hartman, Sun, Devasia, Chase, Jairath, Dess, Jackson, Morris, Hochstedler, Abbott, Kidwell, Walter, M. Wang, X. Wang, Zaorsky, Schipper, Spratt.
Drafting of the manuscript: Hartman, Sun, Devasia, Hochstedler, Kidwell, Schipper, Spratt.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Hartman, Sun, Devasia, Chase, Jairath, Morris, Kidwell, M. Wang, X. Wang, Zaorsky, Schipper.
Obtained funding: Spratt.
Administrative, technical, or material support: Zaorsky, Spratt.
Supervision: Dess, Jackson, Kidwell, Schipper, Spratt.
Conflict of Interest Disclosures: Dr Zaorsky reported receiving grants from the American Cancer Society–CEOs Against Cancer Tri State chapter for clinician scientist development, the National Institutes of Health, the Penn State Cancer Institute, and the Penn State College of Medicine; remuneration from Springer Nature for a published textbook; and personal fees from Weatherby Healthcare outside the submitted work. Dr Schipper reported receiving personal fees from Innovative Analytics outside the submitted work. Dr Spratt reported receiving grants from Janssen Pharmaceuticals and personal fees from AstraZeneca, Blue Earth Diagnostics, and Janssen Pharmaceuticals outside the submitted work. No other disclosures were reported.
Funding/Support: This study was supported by grants P30-CA046592, P50-CA186786, T32-CA083654, and NSF DGE-1256260 from the National Cancer Institute, National Institutes of Health, and National Science Foundation.
Role of the Funder/Sponsor: The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.