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Dyschromic Nails, Exertional Dyspnea, and Lower Extremity Edema

Educational Objective
Based on this clinical scenario and the accompanying image, understand how to arrive at a correct diagnosis.
1 Credit CME

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Article Information

Corresponding Author: Soumya Chatterjee, MD, MS, Orthopaedic and Rheumatologic Institute, Department of Rheumatic and Immunologic Diseases, Cleveland Clinic, 9500 Euclid Ave, Desk A50, Cleveland, OH 44195 (chattes@ccf.org).

Published Online: October 22, 2020. doi:10.1001/jama.2020.14648

Conflict of Interest Disclosures: None reported.

Additional Contributions: We thank the patient for providing permission to share his information.

References
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Vignes  S , Baran  R .  Yellow nail syndrome: a review.   Orphanet J Rare Dis. 2017;12(1):42. doi:10.1186/s13023-017-0594-4PubMedGoogle ScholarCrossref
2.
Preston  A , Altman  K , Walker  G .  Yellow nail syndrome.   Proc (Bayl Univ Med Cent). 2018;31(4):526-527. doi:10.1080/08998280.2018.1487662PubMedGoogle ScholarCrossref
3.
Valdés  L , Huggins  JT , Gude  F ,  et al.  Characteristics of patients with yellow nail syndrome and pleural effusion.   Respirology. 2014;19(7):985-992. doi:10.1111/resp.12357PubMedGoogle ScholarCrossref
4.
Norton  L .  Further observations on the yellow nail syndrome with therapeutic effects of oral alpha-tocopherol.   Cutis. 1985;36(6):457-462.PubMedGoogle Scholar
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Ali  MS , Ghori  UK , Musani  AI .  Orphan lung diseases.   Med Clin North Am. 2019;103(3):503-515. doi:10.1016/j.mcna.2018.12.009PubMedGoogle ScholarCrossref
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