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There are ongoing controversies about the evaluation and dissemination of medical and scientific research.1- 3 Preprint servers offer researchers the opportunity to post manuscripts before publication in peer-reviewed journals and regardless of whether they have been submitted to journals for review. The global coronavirus disease 2019 (COVID-19) pandemic has focused attention on the timely reporting and dissemination of research findings, and the respective roles of preprint servers and traditional peer-reviewed journals. We compared the effect and reach of studies about therapies for COVID-19 posted on the medRxiv preprint server, subsequent publications in medical journals of some of these studies, and journal articles that were not posted on either medRxiv or another preprint server.
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CME Disclosure Statement: Unless noted, all individuals in control of content reported no relevant financial relationships. If applicable, all relevant financial relationships have been mitigated.
Accepted for Publication: September 22, 2020.
Published Online: November 9, 2020. doi:10.1001/jamainternmed.2020.6629
Corresponding Author: Neil W. Schluger, MD, Department of Medicine, New York Medical College, 40 Sunshine Cottage Rd, Valhalla, NY 10595 (email@example.com).
Author Contributions: Dr Schluger had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Concept and design: Jung, Schluger.
Acquisition, analysis, or interpretation of data: All authors.
Drafting of the manuscript: Jung, Schluger.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: All authors.
Administrative, technical, or material support: Jung, Schluger.
Conflict of Interest Disclosures: None reported.
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