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Although much of the response to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has focused on acute coronavirus disease 2019 (COVID-19) illness, accumulating evidence demonstrates morbidity beyond acute SARS-CoV-2 infection.1- 4 At least 2 other periods of illness appear to be temporally associated with SARS-CoV-2 infection: a rare postacute hyperinflammatory illness and late inflammatory and virological sequelae. These 3 illness periods not only define the temporal course of SARS-CoV-2 infection at the population level but also capture distinct phases of host-viral interaction.
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Corresponding Author: Amish Talwar, MD, MPH, US Centers for Disease Control and Prevention, 1600 Clifton Rd NE, Mailstop H21-3, Atlanta, GA 30329 (firstname.lastname@example.org).
Published Online: November 18, 2020. doi:10.1001/jama.2020.22717
Conflict of Interest Disclosures: None reported.
Disclaimer: The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the US Centers for Disease Control and Prevention.
Additional Contributions: We recognize the following members of the US Centers for Disease Control and Prevention COVID-19 clinical team: Michael Melgar, MD, Ermias D. Belay, MD, Kevin R. Clarke, MD, John Iskander, MD, MPH, and John T. Brooks, MD.
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