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Antibodies, Immunity, and COVID-19

Educational Objective
To identify the key insights or developments described in this article
1 Credit CME

Widespread availability of commercial assays that detect anti–severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies has enabled researchers to examine naturally acquired immunity to coronavirus disease 2019 (COVID-19) at the population level. Several studies have found that the SARS-CoV-2 seroprevalence (the percentage of the population with serum containing antibodies that recognize the virus) has remained below 20% even in the most adversely affected areas globally, such as Spain and Italy.13 In this issue of JAMA Internal Medicine, Bajema et al4 contribute new information on the shifting nature of SARS-CoV-2 seroprevalence in the US. The study uses national data to expand on an earlier US Centers for Disease Control and Prevention study of seroprevalence of antibodies to SARS-CoV-2 in 10 US sites.3

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Article Information

Corresponding Author: Brad Spellberg, MD, 2051 Marengo Street, Los Angeles, CA 90033 (bspellberg@dhs.lacounty.gov).

Published Online: November 24, 2020. doi:10.1001/jamainternmed.2020.7986

Conflict of Interest Disclosures: Dr Spellberg reported personal fees from IQVIA and service on multiple data safety monitoring boards for therapeutics for COVID-19, with no financial interest in the sponsors, products, or outcomes of the trials during the conduct of the study. No other disclosures were reported.

References
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Percivalle  E , Cambiè  G , Cassaniti  I ,  et al.  Prevalence of SARS-CoV-2 specific neutralising antibodies in blood donors from the Lodi Red Zone in Lombardy, Italy, as at 06 April 2020.   Euro Surveill. 2020;25(24):2001031.PubMedGoogle Scholar
2.
Pollán  M , Pérez-Gómez  B , Pastor-Barriuso  R ,  et al; ENE-COVID Study Group.  Prevalence of SARS-CoV-2 in Spain (ENE-COVID): a nationwide, population-based seroepidemiological study.   Lancet. 2020;396(10250):535-544. PubMedGoogle ScholarCrossref
3.
Havers  FP , Reed  C , Lim  T ,  et al.  Seroprevalence of Antibodies to SARS-CoV-2 in 10 Sites in the United States, March 23-May 12, 2020.   JAMA Intern Med. 2020. Published online July 21, 2020. doi:10.1001/jamainternmed.2020.4130PubMedGoogle Scholar
4.
Bajema  KL , Wiegand  RE , Cuffe  K ,  et al.  Estimated SARS-CoV-2 seroprevalence in the United States as of September 2020.   JAMA Intern Med. Published online November 24, 2020. doi:10.1001/jamainternmed.2020.7976Google Scholar
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Fontanet  A , Cauchemez  S .  COVID-19 herd immunity: where are we?   Nat Rev Immunol. 2020;20(10):583-584. PubMedGoogle ScholarCrossref
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US Centers for Disease and Prevention. Epidemiology and prevention of vaccine-preventable diseases. Accessed November 1, 2020. https://www.cdc.gov/vaccines/pubs/pinkbook/index.html
7.
Tillett  RL , Sevinsky  JR , Hartley  PD ,  et al.  Genomic evidence for reinfection with SARS-CoV-2: a case study.   Lancet Infect Dis. 2020;S1473-3099(20)30764-7.PubMedGoogle Scholar
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Klein  SL , Pekosz  A , Park  HS ,  et al.  Sex, age, and hospitalization drive antibody responses in a COVID-19 convalescent plasma donor population.   J Clin Invest. 2020;130(11):6141-6150. PubMedGoogle ScholarCrossref
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Dörner  T , Radbruch  A .  Antibodies and B cell memory in viral immunity.   Immunity. 2007;27(3):384-392. PubMedGoogle ScholarCrossref
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