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Pulmonary Fungal Infections Affect Patients With COVID-19

Educational Objective
To identify the key insights or developments described in this article
1 Credit CME

Investigators in Spain and the United States have added 20 new case reports to mounting evidence that patients with coronavirus disease 2019 (COVID-19) are vulnerable to developing pulmonary aspergillosis. Authors of the case series noted that increased physician awareness in recent years of an association between severe influenza and the fungal infection may have led to more rapid recognition of coronavirus disease–associated pulmonary aspergillosis (CAPA).

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CME Disclosure Statement: Unless noted, all individuals in control of content reported no relevant financial relationships. If applicable, all relevant financial relationships have been mitigated.

Investigators in Spain and the United States have added 20 new case reports to mounting evidence that patients with coronavirus disease 2019 (COVID-19) are vulnerable to developing pulmonary aspergillosis. Authors of the case series noted that increased physician awareness in recent years of an association between severe influenza and the fungal infection may have led to more rapid recognition of coronavirus disease–associated pulmonary aspergillosis (CAPA).

The new cases of CAPA were identified at Johns Hopkins Medical Center in Baltimore and the Hospital Clinic of Barcelona in Spain between March and June. Older age, hypertension, and pulmonary disease were common among these patients. Systemic or inhaled steroids, often to manage COVID-19–related inflammation, were the most common immunosuppressive agents associated with CAPA. All but 2 of the 20 patients were treated with intravenous antifungal drugs. Three of the patients died.

AMA CME Accreditation Information

Credit Designation Statement: The American Medical Association designates this Journal-based CME activity activity for a maximum of 1.00  AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to:

  • 1.00 Medical Knowledge MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program;;
  • 1.00 Self-Assessment points in the American Board of Otolaryngology – Head and Neck Surgery’s (ABOHNS) Continuing Certification program;
  • 1.00 MOC points in the American Board of Pediatrics’ (ABP) Maintenance of Certification (MOC) program;
  • 1.00 Lifelong Learning points in the American Board of Pathology’s (ABPath) Continuing Certification program; and
  • 1.00 credit toward the CME [and Self-Assessment requirements] of the American Board of Surgery’s Continuous Certification program

It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting MOC credit.

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