Accepted for Publication: October 16, 2020.
Published Online: December 10, 2020. doi:10.1001/jamaoto.2020.4354
Corresponding Author: Kristian Hutson, MD, James Paget University Hospital, Lowestoft Rd, Gorleston NR316LA, England (kristian.hutson@doctors.net.uk).
Author Contributions: Prof Philpott and Dr Hutson had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.
Concept and design: Hutson, Clark, Philpott.
Acquisition, analysis, or interpretation of data: Hopkins, Ahmed, Kumar, Carrie, Erskine, Sunkaraneni, Philpott.
Drafting of the manuscript: Hutson, Philpott.
Critical revision of the manuscript for important intellectual content: Clark, Hopkins, Ahmed, Kumar, Carrie, Erskine, Sunkaraneni, Philpott.
Statistical analysis: Hutson, Clark.
Obtained funding: Philpott.
Administrative, technical, or material support: Erskine, Philpott.
Supervision: Hopkins, Ahmed, Kumar, Sunkaraneni, Philpott.
CRES Group Members: Carl Philpott (chief investigator), James Paget University Hospital; Claire Hopkins, Guys & St Thomas’ Hospital; Nirmal Kumar, Wrightington, Wigan & Leigh NHS Foundation Trust ; Alasdair Robertson, Southern General Hospital, Glasgow; Amir Farboud, Wrexham Maelor Hospital, Wales; Shahzada Ahmed, University Hospitals Birmingham; Shahram Anari, Heart of England NHS Foundation Trust; Russell Cathcart, Cumberland Infirmary; Hisham Khalil, Derriford Hospital; Paul Jervis, Northampton General Hospital; Sean Carrie, Freeman Hospital, Newcastle; Naveed Kara, Sunderland Royal Infirmary; Peter Prinsley, Norfolk & Norwich University Hospital; Robert Almeyda, Oxford University Hospitals; Nicolas Mansell, Royal Berkshire NHS Foundation Trust; Mahmoud Salam, The Ipswich Hospital; Jaydip Ray, Sheffield Teaching Hospitals; Jaan Panesaar, Luton & Dunstable Hospital; Jonathan Hobson, Warrington and Halton Hospitals NHS Foundation Trust; Vishnu Sunkaraneni, Royal Surrey County Hospital, Guildford; and Allan Clark, Norwich Medical School, University of East Anglia.
Conflict of Interest Disclosures: Dr Philpott reported grants from the National Institute for Health Research and Rosetrees, and personal fees from Sanofi-Genzyme outside the submitted work. No other disclosures were reported.
Funding/Support: The study was funded by the Anthony Long Trust (postage costs) and the Bernice Bibby Trust (research nurse time).
Role of the Funder/Sponsor: The funding organizations had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Additional Information: This study has been reported in accordance with the Strengthening the Reporting of Observational Studies in Epidemiology statement guidelines for the reporting of observational studies.
Additional Contributions: We thank the CRES group of otorhinolaryngologists who recruited patients to the study and Jane Woods, RN, James Paget University Hospital, for her dedication to the study. None of these individuals received compensation for their contributions.
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