Clinical Characteristics and Disease Severity Among Infants With SARS-CoV-2 Infection | Pediatrics | JN Learning | AMA Ed Hub [Skip to Content]
[Skip to Content Landing]

Clinical Characteristics and Disease Severity Among Infants With SARS-CoV-2 Infection in Montreal, Quebec, Canada

Educational Objective
To identify the key insights or developments described in this article
1 Credit CME

With more than 40 million cases of confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection worldwide, the clinical presentation and risk factors for disease severity among adults and children have now been well described.1 SARS-CoV-2 is the virus that causes coronavirus disease 2019. However, little remains known about disease manifestation and severity of illness in infants.2 Although infants are at higher risk of severe disease and complications from other common viral respiratory pathogens (influenza, respiratory syncytial virus), it is not yet clear whether this is the case with SARS-CoV-2 infection because few series describing outcomes in infants have been published.3,4 The objective of this study was to describe the manifestations and severity of disease among infants with SARS-CoV-2 infection.

Sign in to take quiz and track your certificates

Buy This Activity

CME Disclosure Statement: Unless noted, all individuals in control of content reported no relevant financial relationships. If applicable, all relevant financial relationships have been mitigated.

Article Information

Accepted for Publication: October 21, 2020.

Published: December 14, 2020. doi:10.1001/jamanetworkopen.2020.30470

Correction: This article was corrected on February 5, 2021, to fix the spelling of the third author’s first name in the byline.

Open Access: This is an open access article distributed under the terms of the CC-BY License. © 2020 Panetta L et al. JAMA Network Open.

Corresponding Author: Fatima Kakkar, MD, MPH, Division of Infectious Disease, Department of Pediatrics, Centre Hospitalier Universitaire Sainte-Justine, 3175 Chemin de la Côte-Sainte-Catherine, Montreal, QC H3T 1C5, Canada (fatima.kakkar@umontreal.ca).

Author Contributions: Drs Kakkar and Panetta had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.

Concept and design: Panetta, Proulx, Autmizguine, Luu, Kakkar.

Acquisition, analysis, or interpretation of data: Panetta, Proulx, Drouin, Autmizguine, Quach, Kakkar.

Drafting of the manuscript: Panetta, Kakkar.

Critical revision of the manuscript for important intellectual content: All authors.

Statistical analysis: Kakkar.

Obtained funding: Kakkar.

Administrative, technical, or material support: Panetta, Luu, Quach.

Supervision: Drouin, Kakkar.

Conflict of Interest Disclosures: None reported.

Funding/Support: This work was supported by a Réseau SIDA Maladies Infectieuses coronavirus disease 2019 COVID-19 grant to Dr Kakkar that provided funding for the design and conduct of the study, data collection and, management. Drs Kakkar, Drouin, Luu, Autmizgine, and Quach are supported by Fonds de Recherche Santé clinician investigator grants that provide salary support for protected time that allowed for data analysis and manuscript preparation.

Role of the Funder/Sponsor: The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and the decision to submit the manuscript for publication.

Additional Contributions: The authors thank all members of the CHU-Sainte Justine COVID-19 response team, including the COVID-19 outpatient clinic team leader (Geneviève Parisien, BSc), infection control prevention team (Nadia Demarais, RN, and Gaelle Anick Delisle, MSc), pediatric infectious diseases team (Bruce Tapiero, MD, Valerie Lamarre, MD, Philippe Ovetchkine, MD, Marc Lebel, MD, Chantal Buteau MD, and Ana Blanchard, MD, MSc), medical microbiology team (Christian Renaud MD, MSc, Emilie Valières MD, PhD, and Julie Blackburn, MD), and research team of the Centre d’Infectiologie Mère-enfant (Silvie Valois RN, and Suzanne Taillefer, PhD) for their work in rapidly establishing the clinical and research infrastructures needed to address the COVID-19 pandemic at CHU-Sainte-Justine.

References
1.
Wu  Z , McGoogan  JM .  Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72 314 cases from the Chinese Center for Disease Control and Prevention.   JAMA. 2020;323(13):1239-1242. doi:10.1001/jama.2020.2648 PubMedGoogle ScholarCrossref
2.
Vanhems  P , Endtz  H , Dananché  C , Komurian-Pradel  F , Sanchez Picot  V ; Pneumonia Study GABRIEL members.  Comparison of the clinical features of SARS-CoV-2, other coronavirus and influenza infections in infants less than 1-year-old.   Pediatr Infect Dis J. 2020;39(7):e157-e158. doi:10.1097/INF.0000000000002705PubMedGoogle ScholarCrossref
3.
Liu  X , Tang  J , Xie  R ,  et al.  Clinical and epidemiological features of 46 children <1 year old with coronavirus disease 2019 in Wuhan, China: a descriptive study.   J Infect Dis. 2020;222(8):1293-1297. doi:10.1093/infdis/jiaa472 PubMedGoogle ScholarCrossref
4.
Raba  AA , Abobaker  A , Elgenaidi  IS , Daoud  A .  Novel coronavirus infection (COVID-19) in children younger than one year: a systematic review of symptoms, management and outcomes.   Acta Paediatr. 2020;109(10:1948-1955. doi:10.1111/apa.15422 PubMedGoogle Scholar
5.
Dong  Y , Mo  X , Hu  Y ,  et al.  Epidemiology of COVID-19 among children in China.   Pediatrics. 2020;145(6):e20200702. doi:10.1542/peds.2020-0702PubMedGoogle Scholar
6.
CDC COVID-19 Response Team.  Coronavirus disease 2019 in children—United States, February 12-April 2, 2020.   MMWR Morb Mortal Wkly Rep. 2020;69(14):422-426. doi:10.15585/mmwr.mm6914e4 PubMedGoogle ScholarCrossref
Want full access to the AMA Ed Hub?
After you sign up for AMA Membership, make sure you sign in or create a Physician account with the AMA in order to access all learning activities on the AMA Ed Hub
Buy this activity
Close
Want full access to the AMA Ed Hub?
After you sign up for AMA Membership, make sure you sign in or create a Physician account with the AMA in order to access all learning activities on the AMA Ed Hub
Buy this activity
Close
With a personal account, you can:
  • Access free activities and track your credits
  • Personalize content alerts
  • Customize your interests
  • Fully personalize your learning experience
Education Center Collection Sign In Modal Right
Close

Name Your Search

Save Search
Close
With a personal account, you can:
  • Access free activities and track your credits
  • Personalize content alerts
  • Customize your interests
  • Fully personalize your learning experience
Close

Lookup An Activity

or

Close

My Saved Searches

You currently have no searches saved.

Close

My Saved Courses

You currently have no courses saved.

Close
With a personal account, you can:
  • Access free activities and track your credits
  • Personalize content alerts
  • Customize your interests
  • Fully personalize your learning experience
Education Center Collection Sign In Modal Right
Close