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Coronavirus Disease 2019–Associated Ocular Neuropathy With PanuveitisA Case Report

Educational Objective
To identify the key insights or developments described in this article

In December 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) appeared in Wuhan, China. The SARS-CoV-2 virus affects the lungs and other organs and has many different clinical manifestations. Regarding the eye, SARS-CoV-2 is well known to induce conjunctivitis; for example, in a study1 of 38 consecutive patients with coronavirus disease 2019 (COVID-19), 5% had virus-positive conjunctivae and 32% had conjunctivitis. However, whether SARS-CoV-2 can cause significant ocular disease is unknown.2

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Article Information

Corresponding Author: Jean Marc Perone, MD, Ophthalmology Department, Metz-Thionville Regional Hospital Center, Lorraine University, Mercy Hospital, 1 Allee du Chateau, CS 45001 57085 Metz-Cedex 03, France (jm.perone@chr-metz-thionville.fr).

Published Online: December 17, 2020. doi:10.1001/jamaophthalmol.2020.5695

Conflict of Interest Disclosures: None reported.

Additional Contributions: We thank Yinka Zevering, PhD, SciMeditor Medical Writing Services, for her assistance in preparing the manuscript. She was compensated for her contribution. We also thank the patient for granting permission to publish this information.

References
1.
Wu  P , Duan  F , Luo  C ,  et al.  Characteristics of ocular findings of patients with coronavirus disease 2019 (COVID-19) in Hubei province, China.   JAMA Ophthalmol. 2020;138(5):575-578. doi:10.1001/jamaophthalmol.2020.1291PubMedGoogle ScholarCrossref
2.
Seah  I , Agrawal  R .  Can the coronavirus disease 2019 (COVID-19) affect the eyes? a review of coronaviruses and ocular implications in humans and animals.   Ocul Immunol Inflamm. 2020;28(3):391-395. doi:10.1080/09273948.2020.1738501PubMedGoogle ScholarCrossref
3.
Marinho  PM , Marcos  AAA , Romano  AC , Nascimento  H , Belfort  R  Jr .  Retinal findings in patients with COVID-19.   Lancet. 2020;395(10237):1610. doi:10.1016/S0140-6736(20)31014-XPubMedGoogle ScholarCrossref
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Xia  J , Tong  J , Liu  M , Shen  Y , Guo  D .  Evaluation of coronavirus in tears and conjunctival secretions of patients with SARS-CoV-2 infection.   J Med Virol. 2020;92(6):589-594. doi:10.1002/jmv.25725PubMedGoogle ScholarCrossref
5.
Kedar  S , Jayagopal  LN , Berger  JR .  Neurological and ophthalmological manifestations of varicella zoster virus.   J Neuroophthalmol. 2019;39(2):220-231. doi:10.1097/WNO.0000000000000721PubMedGoogle ScholarCrossref
6.
Moriguchi  T , Harii  N , Goto  J ,  et al.  A first case of meningitis/encephalitis associated with SARS-coronavirus-2.   Int J Infect Dis. 2020;94:55-58. doi:10.1016/j.ijid.2020.03.062PubMedGoogle ScholarCrossref
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