National efforts to develop a coronavirus disease 2019 (COVID-19) vaccine at “warp speed” will likely yield a safe and effective vaccine by early 2021. However, this important milestone is only the first step in an equally important challenge: getting a majority of the US public vaccinated. In a September 2020 survey of 10 093 US adults, only 51% indicated that they were definitely or probably willing to be vaccinated with a novel COVID-19 vaccine, 25% reported that they were probably not willing to get the vaccine, and 24% reported that it is unlikely that they would be vaccinated.1 This survey further revealed that acceptance was lower among Black individuals (32%, 263 of 822); those with lower educational attainment (47%, 676 of 1438 among those with high school or less education) compared with college graduates (56%, 1673 of 2988) or those with a postgraduate education (63%, 1693 of 2668); and among Republican voters (44%, 1817 of 4129).1