Accepted for Publication: December 2, 2020.
Published Online: December 29, 2020. doi:10.1001/jamacardio.2020.7308
Corresponding Author: Ana Blasco, MD, PhD, Cardiology Department, Hospital Universitario Puerta de Hierro–Majadahonda, C/Manuel de Falla 1, 28222 Majadahonda, Madrid, Spain (email@example.com).
Author Contributions: Dr Blasco had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Concept and design: Blasco, Goicolea, Del Trigo, Ortega, Silva, Bellas.
Acquisition, analysis, or interpretation of data: Blasco, Coronado, Hernandez-Terciado, Martín, Royuela, Ramil, García, Goicolea, Escudier, Bellas.
Drafting of the manuscript: Blasco, Ramil, García, Del Trigo, Silva.
Critical revision of the manuscript for important intellectual content: Coronado, Hernandez-Terciado, Martín, Royuela, Goicolea, Ortega, Escudier, Bellas.
Statistical analysis: Blasco, Royuela.
Obtained funding: Blasco.
Administrative, technical, or material support: Coronado, Hernandez-Terciado, Martín, Royuela, Ramil, García, Del Trigo, Ortega, Escudier.
Supervision: Royuela, Goicolea, Silva, Bellas.
Conflict of Interest Disclosures: None reported.
Funding/Support: This work was supported by a grant of the Spanish Society of Cardiology.
Role of the Funder/Sponsor: The funder had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Additional Contributions: The authors wish to thank the donors and the Biobank Hospital Universitario Puerta de Hierro–Majadahonda and Instituto de Investigación Sanitaria Puerta de Hierro–Segovia de Arana (PT17/0015/0020 in the Spanish National Biobanks Network) for the human specimens used in this study. Our sincere thanks to the staff members and the nursing team at the Interventional Cardiology Unit, who collected the patient samples, and the cardiology physicians on duty at the Coronary Unit, who participated in the compilation of the clinical information of patients. This work had not been possible without their invaluable assistance.
B , Madhavan
MV , Jiménez
et al; Global COVID-19 Thrombosis Collaborative Group, Endorsed by the ISTH, NATF, ESVM, and the IUA, Supported by the ESC Working Group on Pulmonary Circulation and Right Ventricular Function. COVID-19 and thrombotic or thromboembolic disease: implications for prevention, antithrombotic therapy, and follow-up, JACC state-of-the-art review. J Am Coll Cardiol
. 2020;75(23):2950-2973. doi:10.1016/j.jacc.2020.04.031PubMedGoogle ScholarCrossref
AR , Roch
B . Neutrophil extracellular traps and by-products play a key role in COVID-19: pathogenesis, risk factors, and therapy. J Clin Med
. 2020;9(9):E2942. doi:10.3390/jcm9092942PubMedGoogle Scholar
AM , Graybill
FA . Introduction to the Theory of Statistics. 2nd ed. McGraw–Hill; 1963.
Y , Yalavarthi
S , Shi
et al Neutrophil extracellular traps (NETs) as markers of disease severity in COVID-19. MedRxiv
. 2020; 2020.04.09.20059626.Google Scholar
L , Sonzogni
A , Nasr
et al. Pulmonary post-mortem findings in a large series of COVID-19 cases from Northern Italy: a two-centre descriptive study. Lancet Infect Dis
. 2020;(10):1135-1140. doi:10.1016/S1473-3099(20)30434-5PubMedGoogle Scholar
MS , Ragnhild Helseth
R , Ritschel
et al. Double-stranded DNA and NETs components in relation to clinical outcome after ST-elevation myocardial infarction. Scientific Reports
. 2020;10(1):5007.Google ScholarCrossref