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Physiologic adaptations and changes in immune regulation may increase the risk of morbidity and mortality in pregnant women with respiratory infections.1,2 The effects of coronavirus disease 2019 (COVID-19) in pregnancy have not been fully delineated. We compared the clinical characteristics and outcomes of hospitalized women who gave birth with and without COVID-19.
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Accepted for Publication: December 29, 2020.
Published Online: January 15, 2021. doi:10.1001/jamainternmed.2020.9241
Corresponding Author: Scott D. Solomon, MD, Division of Cardiovascular Medicine, Brigham and Women’s Hospital, 75 Francis St, Boston, MA 02115 (firstname.lastname@example.org).
Author Contributions: Drs Jering and Solomon had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.
Concept and design: Jering, Cunningham, Claggett.
Acquisition, analysis, or interpretation of data: All authors.
Drafting of the manuscript: Jering, Solomon.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Jering, Claggett, Cunningham, Greene.
Obtained funding: Solomon.
Administrative, technical, or material support: Jering.
Conflict of Interest Disclosures: Dr Jering reports being supported by a postdoctoral training grant from the National Heart, Lung, and Blood Institute (NHLBI) (T32HL007604). Dr Claggett reports receiving personal fees from Amgen, Boehringer Ingelheim, Corvia Medical, MyoKardia, and Novartis outside the submitted work. Dr Cunningham reports being supported by a postdoctoral training grant from NHLBI (T32HL094301). Dr Rosenthal reports being an employee of Premier Inc, which curates the Premier Healthcare Database used in this study. Dr Vardeny reports receiving research support from NHLBI, grant support from AstraZeneca and Bayer, and personal fees from the American Heart Association, Novartis, and Sanofi Pasteur outside the submitted work. Dr Solomon reports receiving grants from Actelion, Alnylam, Amgen, AstraZeneca, Bellerophon, Bayer, Bristol Myers Squibb, Celladon, Cytokinetics, Eidos, Gilead Sciences, GlaxoSmithKline, Ionis Pharmaceuticals, LoneStar Heart, Mesoblast, MyoKardia, NeuroTronik, NHLBI, Novartis, Novo Nordisk, Respicardia, Sanofi Pasteur, and Theracos, as well as personal fees from Abbott, Actelion, Akros, Alnylam Pharmaceuticals, Amgen, Arena, AstraZeneca, Bayer, Boehringer Ingelheim, Bristol Myers Squibb, Cardior Pharmaceuticals, Cardurion Pharmaceuticals, Corvia Medical, Cytokinetics, Daiichi Sankyo, Gilead Sciences, GlaxoSmithKline, Ironwood Pharmaceuticals, Eli Lilly, Merck, MyoKardia, Novartis, Roche, Takeda, Theracos, Quantum Genetics, Cardurion Pharmaceuticals, AOBiome, Janssen, Cardiac Dimensions, Sanofi Pasteur, Tenaya, DiNAQOR, Tremeau Pharmaceuticals, CellProthera, and Moderna outside the submitted work. No other disclosures were reported.
Additional Contributions: We thank Muthiah Vaduganathan, MD, MPH, and Ankeet Bhatt, MD, of Brigham and Women’s Hospital for their thoughtful contributions to the study design and revisions of this article. They were not compensated for their contributions.
Additional Information: Qualified researchers can apply for data access directly to Premier Inc.
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