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Dementia and Cognitive Impairment

APOE ɛ4 Allele Testing and Risk of Alzheimer Disease

Educational Objective
To understand how to interpret the results of diagnostic tests and apply them clinically.

1 Credit CME

JAMA

Published Online: January 14, 2021

JAMA Diagnostic Test Interpretation

Article Information and Disclosures

Parichita Choudhury, MD, MSc¹;

Vijay K Ramanan, MD, PhD¹;

Bradley F. Boeve, MD¹

Author Affiliations

¹Division of Behavioral Neurology, Department of Neurology, Mayo Clinic, Rochester, Minnesota

Read article on JAMA Network

Comment & Response

APOE Allele Testing and Alzheimer Disease—Reply

Parichita Choudhury, MD, MSc; Vijay K. Ramanan, MD, PhD; Bradley F. Boeve, MD
Comment & Response

APOE Allele Testing and Alzheimer Disease

Mu-Hong Chen, MD, PhD; Fu-Chi Yang, MD, PhD; Chih-Sung Liang, MD
Original Investigation

Association of African Ancestry–Specific APOE Missense Variant R145C With Risk of Alzheimer Disease

Yann Le Guen, PhD; Ana-Caroline Raulin, PhD; Mark W. Logue, PhD; Richard Sherva, PhD; Michael E. Belloy, PhD; Sarah J. Eger, BA; Annabel Chen, BSc; Gabriel Kennedy, BSc; Lindsey Kuchenbecker, BSc; Justin P. O’Leary, BSc; Rui Zhang, MS; Victoria C. Merritt, PhD; Matthew S. Panizzon, PhD; Richard L. Hauger, MD; J. Michael Gaziano, MD; Guojun Bu, PhD; Timothy A. Thornton, PhD; Lindsay A. Farrer, PhD; Valerio Napolioni, PhD; Zihuai He, PhD; Michael D. Greicius, MD, MPH
Original Investigation

Analysis of Whole-Exome Sequencing Data for Alzheimer Disease Stratified by APOE Genotype

Yiyi Ma, PhD; Gyungah R. Jun, PhD; Xiaoling Zhang, PhD; Jaeyoon Chung, PhD; Adam C. Naj, PhD; Yuning Chen, PhD; Celine Bellenguez, PhD; Kara Hamilton-Nelson, MPH; Eden R. Martin, PhD; Brian W. Kunkle, PhD; Joshua C. Bis, PhD; Stéphanie Debette, MD, PhD; Anita L. DeStefano, PhD; Myriam Fornage, PhD; Gaël Nicolas, MD, PhD; Cornelia van Duijn, PhD; David A. Bennett, MD; Philip L. De Jager, MD, PhD; Richard Mayeux, MD; Jonathan L Haines, PhD; Margaret A. Pericak-Vance, PhD; Sudha Seshadri, MD; Jean-Charles Lambert, PhD; Gerard D. Schellenberg, PhD; Kathryn L. Lunetta, PhD; Lindsay A. Farrer, PhD; for the Alzheimer’s Disease Sequencing Project and Alzheimer’s Disease Exome Sequencing–France Project
Original Investigation

Klotho-VS Heterozygosity and Risk of Alzheimer Disease in Individuals Who Carry APOE4

Michael E. Belloy, PhD; Valerio Napolioni, PhD; Summer S. Han, PhD; Yann Le Guen, PhD; Michael D. Greicius, MD, MPH; for the Alzheimer’s Disease Neuroimaging Initiative
Original Investigation

Association of Variants in the APOE Region With Risk of Alzheimer Disease

Elizabeth E. Blue, PhD; Anqi Cheng, PhD; Sunny Chen, MS; Chang-En Yu, PhD; Alzheimer’s Disease Genetics Consortium

Read Case Take Quiz Answer

A 64-year-old man presented with concern about an abnormal genetic test result for apolipoprotein E (APOE) obtained through his primary care physician. He reported forgetfulness and word-finding difficulties for 3 years but performed all activities of daily living independently and was generally healthy. His father and maternal great aunt developed dementia in their 70s. Physical (including neurologic) examination, basic laboratory studies, and brain magnetic resonance imaging results were normal. The Short Test of Mental Status (STMS) score was 33 (maximal attainable score of 38 indicates best performance). Neuropsychological assessment showed average to above-average performance in all cognitive domains, accounting for age and education. Results of his genetic testing for APOE were reported as follows: “This individual possesses an apolipoprotein E genotype (3 and 4) that indicates, with high specificity, that Alzheimer’s disease is the cause of or a contributor to the observed dementia.”

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A 64-year-old man presented with concern about an abnormal genetic test result for apolipoprotein E (APOE) obtained through his primary care physician. He reported forgetfulness and word-finding difficulties for 3 years but performed all activities of daily living independently and was generally healthy. His father and maternal great aunt developed dementia in their 70s. Physical (including neurologic) examination, basic laboratory studies, and brain magnetic resonance imaging results were normal. The Short Test of Mental Status (STMS) score was 33 (maximal attainable score of 38 indicates best performance). Neuropsychological assessment showed average to above-average performance in all cognitive domains, accounting for age and education. Results of his genetic testing for APOE were reported as follows: “This individual possesses an apolipoprotein E genotype (3 and 4) that indicates, with high specificity, that Alzheimer’s disease is the cause of or a contributor to the observed dementia.”

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Article Information

Corresponding Author: Bradley F. Boeve, MD, Division of Behavioral Neurology, Department of Neurology, Mayo Clinic, 200 First St SW, Rochester, MN 55905 (bboeve@mayo.edu).

Published Online: January 14, 2021. doi:10.1001/jama.2020.15085

Author Contributions: Dr Choudhury and Dr Ramanan contributed equally to this article.

Conflict of Interest Disclosures: Dr Boeve reported grants from Biogen, Alector, EIP Pharma, and personal fees from Rainwater Charitable Foundation outside the submitted work. No other disclosures were reported.

Additional Contributions: We thank the patient for granting permission to publish this information.

References

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Elias-Sonnenschein LS , Viechtbauer W , Ramakers IH , Verhey FR , Visser PJ . Predictive value of APOE-ε4 allele for progression from MCI to AD-type dementia: a meta-analysis. J Neurol Neurosurg Psychiatry. 2011;82(10):1149-1156. doi:10.1136/jnnp.2010.231555 PubMed Google Scholar Crossref

Qian J , Wolters FJ , Beiser A , et al. APOE-related risk of mild cognitive impairment and dementia for prevention trials: an analysis of four cohorts. PLoS Med. 2017;14(3):e1002254. doi:10.1371/journal.pmed.1002254 PubMed Google Scholar

Naj AC , Jun G , Reitz C , et al; Alzheimer Disease Genetics Consortium. Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study. JAMA Neurol. 2014;71(11):1394-1404. doi:10.1001/jamaneurol.2014.1491 PubMed Google Scholar Crossref

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Cannon-Albright LA , Foster NL , Schliep K , et al. Relative risk for Alzheimer disease based on complete family history. Neurology. 2019;92(15):e1745-e1753. doi:10.1212/WNL.0000000000007231 PubMed Google Scholar Crossref

Rabinovici GD , Gatsonis C , Apgar C , et al. Association of amyloid positron emission tomography with subsequent change in clinical management among Medicare beneficiaries with mild cognitive impairment or dementia. JAMA. 2019;321(13):1286-1294. doi:10.1001/jama.2019.2000 PubMed Google Scholar Crossref

Brookmeyer R , Abdalla N . Estimation of lifetime risks of Alzheimer’s disease dementia using biomarkers for preclinical disease. Alzheimers Dement. 2018;14(8):981-988. doi:10.1016/j.jalz.2018.03.005 PubMed Google Scholar Crossref

Bateman RJ , Barthélemy NR , Horie K . Another step forward in blood-based diagnostics for Alzheimer’s disease. Nat Med. 2020;26(3):314-316. doi:10.1038/s41591-020-0797-4 PubMed Google Scholar Crossref

Arvanitakis Z , Shah RC , Bennett DA . Diagnosis and management of dementia: review. JAMA. 2019;322(16):1589-1599. doi:10.1001/jama.2019.4782 PubMed Google Scholar Crossref

AMA CME Accreditation Information

Credit Designation Statement: The American Medical Association designates this Journal-based CME activity activity for a maximum of 1.00  AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to:

1.00 Medical Knowledge MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program;;
1.00 Self-Assessment points in the American Board of Otolaryngology – Head and Neck Surgery’s (ABOHNS) Continuing Certification program;
1.00 MOC points in the American Board of Pediatrics’ (ABP) Maintenance of Certification (MOC) program;
1.00 Lifelong Learning points in the American Board of Pathology’s (ABPath) Continuing Certification program; and
1.00 credit toward the CME of the American Board of Surgery’s Continuous Certification program

It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting MOC credit.