Absent Blood Oxygen Level–Dependent Functional Magnetic Resonance Imaging Activation of the Orbitofrontal Cortex in a Patient With Persistent Cacosmia and Cacogeusia After COVID-19 Infection | Neurology | JN Learning | AMA Ed Hub [Skip to Content]
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Absent Blood Oxygen Level–Dependent Functional Magnetic Resonance Imaging Activation of the Orbitofrontal Cortex in a Patient With Persistent Cacosmia and Cacogeusia After COVID-19 Infection

Educational Objective
To identify the key insights or developments described in this article
1 Credit CME

A 25-year-old woman with no relevant medical history developed fever, generalized body pain, dry cough, anosmia, and ageusia in April 2020. She was diagnosed with coronavirus disease 2019 (COVID-19) by positive findings on polymerase chain reaction assay and positive findings on computed tomography of the chest. Her clinical course was uncomplicated, and she was treated conservatively. Anosmia and ageusia started to improve during the following month. However, during the recovery phase, she started to experience offensive odor (cacosmia) and taste (cacogeusia) with stimulation of these sensations. Ear, nose, and throat evaluation showed normal clinical and endoscopic nasal examination findings. Computed tomography findings of the paranasal sinuses were unremarkable. She was given oral and intranasal corticosteroids, in addition to multivitamins, zinc, and olfactory training. However, her symptoms persisted for 3 months, and she was referred to our neurology clinic for further evaluation. Findings of her neurological examination were normal.

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CME Disclosure Statement: Unless noted, all individuals in control of content reported no relevant financial relationships. If applicable, all relevant financial relationships have been mitigated.

Article Information

Corresponding Author: Khaled A. Gad, MD, Department of Radiology, Ibn Sina Hospital, Gamal Abdel Nasser St, Sabah Health Region, Kuwait (khaledgad611@gmail.com).

Published Online: January 22, 2021. doi:10.1001/jamaneurol.2021.0009

Conflict of Interest Disclosures: None reported.

Additional Contributions: We thank the patient for granting permission to publish this information.

References
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