Asymptomatic SARS-CoV-2 Infections Among Persons Entering China From April 16 to October 12, 2020 | Global Health | JN Learning | AMA Ed Hub [Skip to Content]
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Asymptomatic SARS-CoV-2 Infections Among Persons Entering China From April 16 to October 12, 2020

Educational Objective
To identify the key insights or developments described in this article

The magnitude of asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is a question of global concern. Individuals who test positive for SARS-CoV-2 infection via a polymerase chain reaction (PCR) test but lack coronavirus disease 2019 (COVID-19)–like symptoms must be followed up through the incubation period to distinguish individuals with asymptomatic infection from those with presymptomatic infection.1

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Article Information

Accepted for Publication: November 16, 2020.

Corresponding Author: Zunyou Wu, MD, PhD, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, 155 Changbai Rd, Changping District, Beijing 102206, China (wuzy@263.net).

Author Contributions: Dr Wu had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.

Concept and design: Wu.

Acquisition, analysis, or interpretation of data: Ren, Zhang, Li, McGoogan, Feng, Gao, Wu.

Drafting of the manuscript: Ren, Wu.

Critical revision of the manuscript for important intellectual content: Zhang, Li, McGoogan, Feng, Gao, Wu.

Statistical analysis: Ren, Wu.

Obtained funding: Wu.

Administrative, technical, or material support: Li, McGoogan, Feng, Gao, Wu.

Supervision: Zhang, Wu.

Conflict of Interest Disclosures: None reported.

Funding/Support: This study was supported by grant 2020YFC0846300 from the Chinese Ministry of Science and Technology and grant 1G11TW010941 from the Fogarty International Center at the US National Institutes of Health.

Role of the Funder/Sponsor: The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.

Disclaimer: The opinions expressed herein reflect the collective views of the authors and do not necessarily represent the official position of the Chinese Center for Disease Control and Prevention.

References
1.
Wu  Z , McGoogan  JM .  Asymptomatic and pre-symptomatic COVID-19 in China.   Infect Dis Poverty. 2020;9(1):72. doi:10.1186/s40249-020-00679-2PubMedGoogle ScholarCrossref
2.
Zhou  L , Wu  Z , Li  Z ,  et al; China COVID-19 Task Force.  One hundred days of COVID-19 prevention and control in China.   Clin Infect Dis. Published online June 5, 2020. doi:10.1093/cid/ciaa725PubMedGoogle Scholar
3.
World Health Organization. WHO COVID-19 case definition. Accessed September 19, 2020. https://www.who.int/ publications/i/item/WHO-2019-nCoV-Surveillance_Case_Definition-2020.1
4.
Davies  NG , Klepac  P , Liu  Y , Prem  K , Jit  M , Eggo  RM ; CMMID COVID-19 Working Group.  Age-dependent effects in the transmission and control of COVID-19 epidemics.   Nat Med. 2020;26(8):1205-1211. doi:10.1038/s41591-020-0962-9PubMedGoogle ScholarCrossref
5.
Stokes  EK , Zambrano  LD , Anderson  KN ,  et al.  Coronavirus disease 2019 case surveillance—United States, January 22–May 30, 2020.   MMWR Morb Mortal Wkly Rep. 2020;69(24):759-765. doi:10.15585/mmwr.mm6924e2PubMedGoogle ScholarCrossref
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