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Biological activity of vitamin D and its metabolites include, among other properties, potent antimicrobial and anti-inflammatory effects in vitro.1 In animal models, administration of vitamin D metabolites attenuates a variety of acute organ dysfunction, including acute lung injury.2 Observational data from patient cohorts support the potential therapeutic application of these findings.3 Specifically, lower circulating levels of vitamin D metabolites are independently associated with worse outcomes in patients with acute illness, including patients with coronavirus disease 2019 (COVID-19).4
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CME Disclosure Statement: Unless noted, all individuals in control of content reported no relevant financial relationships. If applicable, all relevant financial relationships have been mitigated.
Corresponding Author: Adit A. Ginde, MD, MPH, Department of Emergency Medicine, University of Colorado School of Medicine, 12401 E 17th Ave, B-215, Aurora, CO 80045 (email@example.com).
Published Online: February 17, 2021. doi:10.1001/jama.2020.26850
Conflict of Interest Disclosures: Dr Leaf is supported by grants from the National Institutes of Heath (R01HL144566 and R01DK125786). Dr Ginde reported receiving grants from the National Institutes of Health (U01HL123010, R01HL544166, R01HL149422, 1OT2HL156812, 3UL1TR002243), the Centers for Disease Control and Prevention (contract 75D30120R67837), and the US Department of Defense (contracts BA190054, MTEC-19-08-MuLTI-0043, JW190515, BA190049, FA8650-20-2-6227) outside the submitted work.
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