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Respiratory Failure and Ventilation

Discriminant Accuracy of the SOFA Score for Determining the Probable Mortality of Patients With COVID-19 Pneumonia Requiring Mechanical Ventilation

Educational Objective
To identify the key insights or developments described in this article

1 Credit CME

JAMA

Published Online: February 17, 2021

Research Letter

Article Information and Disclosures

Robert A. Raschke, MD¹;

Sumit Agarwal, MBBS, MBA²;

Pooja Rangan, MBBS, MPH³;

C. William Heise, MD¹;

Steven C. Curry, MD¹

Author Affiliations

¹Division of Clinical Data Analytics and Decision Support, University of Arizona College of Medicine, Phoenix
²College of Medicine, University of Arizona, Phoenix
³Department of Internal Medicine, Banner–University Medical Center Phoenix, Phoenix, Arizona

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Original Investigation

Prognostic Accuracy of SIRS Criteria and SOFA and qSOFA Scores Among ICU Patients With Suspected Infection

Eamon P. Raith, MBBS, MACCP; Andrew A. Udy, MBChB, PhD, FCICM; Michael Bailey, PhD; Steven McGloughlin, BMed FRACP, FCICM, MPHTM; Christopher MacIsaac, MBBS, PhD, FRACP, FCICM; Rinaldo Bellomo, MD, FRACP, FCICM, FAHMS; David V. Pilcher, MBBS, FRACP, FCICM; for the Australian and New Zealand Intensive Care Society (ANZICS) Centre for Outcomes and Resource Evaluation (CORE)
Original Investigation

Risk Score for Development of Critical Illness in Patients With COVID-19

Wenhua Liang, MD; Hengrui Liang, MD; Limin Ou, MD; Binfeng Chen, MD; Ailan Chen, MD; Caichen Li, MD; Yimin Li, MD; Weijie Guan, MD; Ling Sang, MD; Jiatao Lu, MD; Yuanda Xu, MD; Guoqiang Chen, MD; Haiyan Guo, MD; Jun Guo, MD; Zisheng Chen, MD; Yi Zhao, MD; Shiyue Li, MD; Nuofu Zhang, MD; Nanshan Zhong, MD; Jianxing He, MD; for the China Medical Treatment Expert Group for COVID-19
Original Investigation

Effect of Dexamethasone on Ventilator-Free Days in Patients With Moderate or Severe COVID-19–Related ARDS

Bruno M. Tomazini, MD; Israel S. Maia, MD, MSc; Alexandre B. Cavalcanti, MD, PhD; Otavio Berwanger, MD, PhD; Regis G. Rosa, MD, PhD; Viviane C. Veiga, MD, PhD; Alvaro Avezum, MD, PhD; Renato D. Lopes, MD, PhD; Flavia R. Bueno, MSc; Maria Vitoria A. O. Silva; Franca P. Baldassare; Eduardo L. V. Costa, MD, PhD; Ricardo A. B. Moura, MD; Michele O. Honorato, MD; Andre N. Costa, MD, PhD; Lucas P. Damiani, MSc; Thiago Lisboa, MD, PhD; Letícia Kawano-Dourado, MD, PhD; Fernando G. Zampieri, MD, PhD; Guilherme B. Olivato, MD; Cassia Righy, MD, PhD; Cristina P. Amendola, MD; Roberta M. L. Roepke, MD; Daniela H. M. Freitas, MD; Daniel N. Forte, MD, PhD; Flávio G. R. Freitas, MD, PhD; Caio C. F. Fernandes, MD; Livia M. G. Melro, MD; Gedealvares F. S. Junior, MD; Douglas Costa Morais; Stevin Zung, MD, PhD; Flávia R. Machado, MD, PhD; Luciano C. P. Azevedo, MD, PhD; COALITION COVID-19 Brazil III Investigators

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Article Information

Accepted for Publication: February 1, 2021.

Published Online: February 17, 2021. doi:10.1001/jama.2021.1545

Corresponding Author: Robert A. Raschke, MD, 475 N Fifth St, Phoenix, AZ 85004 (raschkebob@gmail.com).

Author Contributions: Dr Raschke had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.

Concept and design: Raschke, Rangan, Heise, Curry.

Acquisition, analysis, or interpretation of data: All authors.

Drafting of the manuscript: Raschke, Rangan, Heise.

Critical revision of the manuscript for important intellectual content: All authors.

Statistical analysis: Raschke, Agarwal, Rangan, Heise.

Administrative, technical, or material support: Agarwal, Heise, Curry.

Supervision: Heise.

Conflict of Interest Disclosures: None reported.

Funding/Support: Funded in part by grant 2196 from the Flinn Foundation.

Role of the Funder/Sponsor: The Flinn Foundation had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.

References

Truog RD , Mitchell C , Daley GQ . The toughest triage—allocating ventilators in a pandemic. N Engl J Med. 2020;382(21):1973-1975. doi:10.1056/NEJMp2005689 PubMed Google Scholar Crossref

Antommaria AHM , Gibb TS , McGuire AL , et al. Ventilator triage policies during the COVID-19 pandemic at US hospitals associated with members of the Association of Bioethics Program Directors. Ann Intern Med. 2020;173(3):188-194. doi:10.7326/M20-1738 PubMed Google Scholar Crossref

Seymour CW , Liu VX , Iwashyna TJ , et al. Assessment of clinical criteria for sepsis: for the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA. 2016;315(8):762-774. doi:10.1001/jama.2016.0288 PubMed Google Scholar Crossref

Raith EP , Udy AA , Bailey M , et al. Prognostic accuracy of the SOFA score, SIRS criteria, and qSOFA score for in-hospital mortality among adults with suspected infection admitted to the intensive care unit. JAMA. 2017;317(3):290-300. doi:10.1001/jama.2016.20328 PubMed Google Scholar Crossref

Gupta S , Hayek SS , Wang W , et al; STOP-COVID Investigators. Factors associated with death in critically ill patients with coronavirus disease 2019 in the US. JAMA Intern Med. 2020;180:1436-1446. doi:10.1001/jamainternmed.2020.3596 PubMed Google Scholar Crossref

Kovach CP , Fletcher GS , Rudd KE , Grant RM , Carlbom DJ . Comparative prognostic accuracy of sepsis scores for hospital mortality in adults with suspected infection in non-ICU and ICU at an academic public hospital. PLoS One. 2019;14(9):e0222563. doi:10.1371/journal.pone.0222563 PubMed Google Scholar

AMA CME Accreditation Information

Credit Designation Statement: The American Medical Association designates this Journal-based CME activity activity for a maximum of 1.00  AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to:

1.00 Medical Knowledge MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program;;
1.00 Self-Assessment points in the American Board of Otolaryngology – Head and Neck Surgery’s (ABOHNS) Continuing Certification program;
1.00 MOC points in the American Board of Pediatrics’ (ABP) Maintenance of Certification (MOC) program;
1.00 Lifelong Learning points in the American Board of Pathology’s (ABPath) Continuing Certification program; and
1.00 CME points in the American Board of Surgery’s (ABS) Continuing Certification program

It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting MOC credit.