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How to Advise Persons Who Are Antibody Positive for SARS-CoV-2 About Future Infection Risk

Educational Objective
To identify the key insights or developments described in this article
1 Credit CME

As a physician working in New York, New York, where coronavirus disease 2019 (COVID-19) hit hard in March and April of 2020, people often ask me how to interpret their severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibody results. Many people have positive test results for the antibody, some of them received a diagnosis of COVID-19, some of them had symptoms that were consistent with COVID-19 but were never tested because of a limited availability of testing, and some were never symptomatic but learned that they were positive for the antibody on a subsequent laboratory test. If they are positive, they want to know whether they are protected from a future infection with the virus.

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Article Information

Published Online: February 24, 2021. doi:10.1001/jamainternmed.2021.0374

Corresponding Author: Mitchell H. Katz, MD, NYC Health and Hospitals, 125 Worth St, Room 514, New York, NY 10013 (mitchell.katz@nychhc.org).

Conflict of Interest Disclosures: None reported.

References
1.
Harvey  RA , Rassen  JA , Kabelac  CA ,  et al.  Association of SARS-CoV-2 seropositive antibody test with risk of future infection.   JAMA Intern Med. Published online February 24, 2021. doi:10.1001/jamainternmed.2021.0366Google Scholar
2.
Lumley  SF , O’Donnell  D , Stoesser  NE ,  et al; Oxford University Hospitals Staff Testing Group.  Antibody status and incidence of SARS-CoV-2 infection in health care workers.   N Engl J Med. 2020. doi:10.1056/NEJMoa2034545PubMedGoogle Scholar
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