Marcus et al1 report on an encouraging coronavirus disease 2019 (COVID-19) control success story that public health officials serving similar high-risk populations may wish to emulate. From May 11 to August 24, 2020, 263 consecutive cohorts (30-50 persons each) of healthy young adults arrived at US Air Force Joint Base San Antonio–Lackland for recruit training. The trainees were screened twice during a 14-day quarantine period and closely monitored for COVID-19 infections. The multifaceted control plan was associated with a reduction in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission among the 10 613 trainees, and the authors used the complex surveillance data to identify some unique findings that might have been missed in studying smaller populations. The authors found that patients with more symptoms and lower SARS-CoV-2–positive cycle threshold assay values were associated with more viral transmission among their peers. The authors found that the multiple COVID-19 interventions at Joint Base San Antonio–Lackland worked well, and there was sparse evidence of asymptomatic superspreaders. This successful control program, which took place in such a historically high-risk setting (ie, a military training camp), may be a useful guide for public health officials working to halt transmission in confined settings.