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Household Transmission of SARS-CoV-2

Educational Objective
To identify the key insights or developments described in this article
1 Credit CME

The primary mode of spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)—the virus that causes coronavirus disease 2019 (COVID-19)—is by person-to-person contact via respiratory droplets.1 Given that most virus transmission has occurred in homes,2 we investigated whether home addresses recorded in the electronic medical record could be used to accurately estimate transmission risk and identify risk factors for transmission.

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Article Information

Accepted for Publication: January 7, 2021.

Published: February 26, 2021. doi:10.1001/jamanetworkopen.2021.0304

Open Access: This is an open access article distributed under the terms of the CC-BY License. © 2021 Metlay JP et al. JAMA Network Open.

Corresponding Author: Joshua P. Metlay, MD, PhD, Division of General Internal Medicine, Department of Medicine, Massachusetts General Hospital, 100 Cambridge St, 16th Floor, Boston, MA 02114 (jmetlay@mgh.harvard.edu).

Author Contributions: Dr Metlay had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.

Concept and design: Metlay, Haas, Armstrong.

Acquisition, analysis, or interpretation of data: All authors.

Drafting of the manuscript: Metlay.

Critical revision of the manuscript for important intellectual content: All authors.

Statistical analysis: Metlay, Armstrong.

Administrative, technical, or material support: Metlay, Soltoff.

Supervision: Haas.

Conflict of Interest Disclosures: None reported.

References
1.
Meyerowitz  EA , Richterman  A , Gandhi  RT , Sax  PE .  Transmission of SARS-CoV-2: a review of viral, host, and environmental factors.   Ann Intern Med. 2021;174(1):69-79. doi:10.7326/M20-5008PubMedGoogle ScholarCrossref
2.
Massachusetts Department of Public Health COVID-19 Dashboard. Weekly COVID-19 public health report. Published October 29, 2020. Accessed November 1, 2020. https://www.mass.gov/doc/weekly-covid-19-public-health-report-october-29-2020/download
3.
Luo  L , Liu  D , Liao  X ,  et al.  Contact settings and risk for transmission in 3410 close contacts of patients with COVID-19 in Guangzhou, China: a prospective cohort study.   Ann Intern Med. 2020;173(11):879-887. doi:10.7326/M20-2671 PubMedGoogle ScholarCrossref
4.
Madewell  ZJ , Yang  Y , Longini  IM  Jr , Halloran  ME , Dean  NE .  Household transmission of SARS-CoV-2: a systematic review and meta-analysis.   JAMA Netw Open. 2020;3(12):e2031756. doi:10.1001/jamanetworkopen.2020.31756 PubMedGoogle Scholar
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