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As a consequence of increasing reports of an unusual and novel presentation of a multisystem inflammatory disease in the UK, the Royal College of Paediatrics and Child Health published a case definition on May 1, 2020, of pediatric inflammatory multisystem syndrome temporally associated with coronavirus disease 2019 (COVID-19) (PIMS-TS).1 They defined PIMS-TS as persistent fever, inflammation, and evidence of single or multiorgan dysfunction, with exclusion of any other microbial cause and with positive or negative severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) polymerase chain reaction test results. In the US, this condition has been defined by the Centers for Disease Control and Prevention as multisystem inflammatory syndrome in children, with a more specific case definition.2
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CME Disclosure Statement: Unless noted, all individuals in control of content reported no relevant financial relationships. If applicable, all relevant financial relationships have been mitigated.
Accepted for Publication: December 20, 2020.
Published Online: February 25, 2021. doi:10.1001/jamaoto.2020.5698
Corresponding Author: Ryan C. T. Cheong, BSc(Hons), MBBS, Ear, Nose and Throat Department, Great Ormond Street Hospital for Children NHS Trust, Great Ormond Street, London WC1N 3JH, United Kingdom (firstname.lastname@example.org).
Author Contributions: Mr Cheong had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Concept and design: Cheong, Frauenfelder, Moshal, Butler, Wyatt.
Acquisition, analysis, or interpretation of data: Cheong, Jephson, Frauenfelder, Cavalli, Butler, Wyatt.
Drafting of the manuscript: Cheong, Frauenfelder, Wyatt.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Cheong.
Administrative, technical, or material support: Cheong, Frauenfelder, Moshal, Wyatt.
Supervision: Cheong, Jephson, Cavalli, Moshal, Butler, Wyatt.
Conflict of Interest Disclosures: None reported.
Additional Contributions: Delane Shingadia, MBChB, DCH, DTM&H, MPH, provided editing assistance; Justin Penner, MD, MSc, DTM&H, assisted in data collection and analysis; and Karlie Grant, BN, assisted in data collection; all with Great Ormond Street Hospital for Children NHS Trust.
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