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Outcomes and Mortality Among Adults Hospitalized With COVID-19 at US Medical Centers

Educational Objective
To identify the key insights or developments described in this article
1 Credit CME

Coronavirus disease 2019 (COVID-19) originally emerged from China and has since spread globally, with almost 14 million confirmed cases and more than 260 000 deaths in the US as of December 1, 2020.1 To date, there have been regional reports on outcomes among patients who developed serious symptoms requiring hospitalization.25 The objectives of our study were to examine the characteristics and outcomes among adults hospitalized with COVID-19 at US medical centers and analyze changes in mortality over the initial 6-month period of the pandemic.

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CME Disclosure Statement: Unless noted, all individuals in control of content reported no relevant financial relationships. If applicable, all relevant financial relationships have been mitigated.

Article Information

Accepted for Publication: January 10, 2021.

Published: March 5, 2021. doi:10.1001/jamanetworkopen.2021.0417

Open Access: This is an open access article distributed under the terms of the CC-BY License. © 2021 Nguyen NT et al. JAMA Network Open.

Corresponding Author: Ninh T. Nguyen, MD, Department of Surgery, University of California, Irvine Medical Center, 333 City Building West, Ste 1600, Orange, CA 92868 (ninhn@uci.edu).

Author Contributions: Dr Nguyen had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.

Concept and design: Nguyen, Chinn, Yuen, Hohmann.

Acquisition, analysis, or interpretation of data: All authors.

Drafting of the manuscript: Nguyen, Chinn, Yuen, Kirby, Amin.

Critical revision of the manuscript for important intellectual content: Nguyen, Chinn, Nahmias, Yuen, Hohmann, Amin.

Statistical analysis: Kirby, Hohmann, Amin.

Administrative, technical, or material support: Nguyen, Chinn, Amin.

Supervision: Nguyen, Nahmias.

Conflict of Interest Disclosures: Dr Amin reported serving as principal investigator or coinvestigator of clinical trials sponsored by the National Institute of Allergy and Infectious Diseases/National Institutes of Health, NeuroRx Pharma, Pulmotect, Blade Therapeutics, Novartis, Takeda, Humanigen, Eli Lilly and Company, PTC Therapeutics, OctaPharma, Fulcrum Therapeutics, and Alexion and serving as speaker and/or consultant for BMS, Pfizer, Boehringer Ingelheim, Portola, Sunovion, Mylan, Salix, Alexion, AstraZeneca, Novartis, Nabriva, Paratek, Bayer, Tetraphase, Achogen LaJolla, Millenium, HeartRite, Aseptiscope, and Sprightly. Dr Nguyen reported serving as a speaker for Olympus and Endogastric Solutions. No other disclosures were reported.

References
1.
US Centers for Disease Control and Prevention. Coronavirus disease 2019 (COVID-19) data tracker. Accessed October 30, 2020. https://covid.cdc.gov/covid-data-tracker/#cases_casesinlast7days
2.
Richardson  S , Hirsch  JS , Narasimhan  M ,  et al; Northwell COVID-19 Research Consortium.  Presenting characteristics, comorbidities, and outcomes among 5700 patients hospitalized with COVID-19 in the New York City area.   JAMA. 2020;323(20):2052-2059. doi:10.1001/jama.2020.6775PubMedGoogle ScholarCrossref
3.
Imam  Z , Odish  F , Gill  I ,  et al.  Older age and comorbidity are independent mortality predictors in a large cohort of 1305 COVID-19 patients in Michigan, United States.   J Intern Med. 2020;288(4):469-476. doi:10.1111/joim.13119PubMedGoogle ScholarCrossref
4.
Petrilli  CM , Jones  SA , Yang  J ,  et al.  Factors associated with hospital admission and critical illness among 5279 people with coronavirus disease 2019 in New York City: prospective cohort study.   BMJ. 2020;369:m1966. doi:10.1136/bmj.m1966PubMedGoogle ScholarCrossref
5.
Gold  JAW , Wong  KK , Szablewski  CM ,  et al.  Characteristics and clinical outcomes of adult patients hospitalized with COVID-19—Georgia, March 2020.   MMWR Morb Mortal Wkly Rep. 2020;69(18):545-550. doi:10.15585/mmwr.mm6918e1PubMedGoogle ScholarCrossref
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