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Binding and Neutralization Antibody Titers After a Single Vaccine Dose in Health Care Workers Previously Infected With SARS-CoV-2

Educational Objective
To identify the key insights or developments described in this article
1 Credit CME

Current shortages in COVID-19 vaccine production and distribution have led some experts to suggest untested regimens.1 Persons who have had COVID-19 are thought to have protective immunity and memory responses2 for at least 6 months; however, neither recall responses nor ideal vaccine dosing regimens have been studied in those previously infected with SARS-CoV-2. We assessed whether health care workers with previous COVID-19 infection could mount recall responses to a single dose of an mRNA-based COVID-19 vaccine.

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Article Information

Accepted for Publication: February 22, 2021.

Published Online: March 1, 2021. doi:10.1001/jama.2021.3341

Corresponding Author: Mohammad M. Sajadi, MD, Institute of Human Virology, Global Virus Network Center of Excellence, University of Maryland School of Medicine, 725 W Lombard St (N548), Baltimore, MD 21201 (msajadi@ihv.umaryland.edu).

Author Contributions: Dr Sajadi had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Drs Harris and Sajadi are co–senior authors.

Concept and design: Newman, Harris, Sajadi.

Acquisition, analysis, or interpretation of data: All authors.

Drafting of the manuscript: Frieman, Harris, Sajadi.

Critical revision of the manuscript for important intellectual content: All authors.

Statistical analysis: Rikhtegaran Tehrani, Frieman, Harris, Sajadi.

Obtained funding: Frieman, Harris.

Administrative, technical, or material support: Saadat, Rikhtegaran Tehrani, Newman, Frieman, Sajadi.

Supervision: Frieman, Sajadi.

Conflict of Interest Disclosures: Dr Harris reported receiving grants from CDC Covid Supplement during the conduct of the study. No other disclosures were reported.

Additional Contributions: We thank all of the study participants who donated their time and samples.

References
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Winter  L . US officials debate efficacy of half doses of COVID-19 vaccine. The Scientist. Published January 5, 2021. Accessed February 13, 2021. https://www.the-scientist.com/news-opinion/us-officials-debate-efficacy-of-half-doses-of-covid-19-vaccine-68316
2.
Dan  JM , Mateus  J , Kato  Y ,  et al.  Immunological memory to SARS-CoV-2 assessed for up to 8 months after infection.   Science. 2021;371(6529):eabf4063. doi:10.1126/science.abf4063PubMedGoogle Scholar
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Mullins  KE , Merrill  V , Ward  M ,  et al.  Validation of COVID-19 serologic tests and large scale screening of asymptomatic healthcare workers.   Clin Biochem. 2021;S0009-9120(21)00005-9.PubMedGoogle Scholar
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Rikhtegaran Tehrani  Z , Saadat  S , Saleh  E ,  et al.  Performance of nucleocapsid and spike-based SARS-CoV-2 serologic assays.   PLoS One. 2020;15(11):e0237828. doi:10.1371/journal.pone.0237828PubMedGoogle Scholar
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Keech  C , Albert  G , Cho  I ,  et al.  Phase 1-2 trial of a SARS-CoV-2 recombinant spike protein nanoparticle vaccine.   N Engl J Med. 2020;383(24):2320-2332. doi:10.1056/NEJMoa2026920PubMedGoogle ScholarCrossref
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Haute Autorité de Santé (HAS). Stratégie de vaccination contre le SARS-CoV-2: vaccination des personnes ayant un antécédent de Covid-19 [SARS-CoV-2 vaccination strategy: vaccination of people with a history of Covid-19]. Published February 11, 2021. Accessed February 13, 2021. https://www.has-sante.fr/upload/docs/application/pdf/2021-02/strategie_de_vaccination_contre_le_sars-cov-2___vaccination_des_personnes_ayant_un_antecedent_de_covid-19_-_synthese.pdf
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