In a recent case report, a team of physicians described an immunosuppressed patient with severe coronavirus disease 2019 (COVID-19) who was contagious for more than 2 months. Infectious virus was present in the patient’s endotracheal aspirate (ETA) 72 days after his COVID-19 diagnosis and 2 days before he died from the massive lung infection. The findings from the 73-year-old man, who had recently undergone chimeric antigen receptor T-cell (CAR-T) therapy, suggest that patients with COVID-19 who are severely immunosuppressed may need isolation for longer than the currently recommended 20 days.
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The patient with treatment–resistant multiple myeloma was first admitted to the intensive care unit (ICU) for COVID-19 symptoms 25 days after a CAR-T–cell infusion, which was preceded by lymphodepletion. As a result, the patient had a diminished T-cell response and an almost nonexistent antibody response.
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