Accepted for Publication: February 4, 2021.
Published Online: March 18, 2021. doi:10.1001/jamaoncol.2021.0310
Corresponding Author: Jun J. Mao, MD, MSCE, Integrative Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, 1429 First Ave, New York, NY 10021 (email@example.com).
Author Contributions: Dr Mao had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Concept and design: Mao, Romero, Gallagher.
Acquisition, analysis, or interpretation of data: All authors.
Drafting of the manuscript: Mao, Liou, Baser, Panageas, Romero, Li.
Critical revision of the manuscript for important intellectual content: Mao, Liou, Baser, Bao, Panageas, Gallagher, Kantoff.
Statistical analysis: Baser, Panageas, Li.
Obtained funding: Mao.
Administrative, technical, or material support: Mao, Liou, Romero, Gallagher.
Supervision: Mao, Panageas, Kantoff.
Conflict of Interest Disclosures: Dr Mao reports grants from Tibet Cheezheng Tibetan Medicine Co Ltd and Zhongke Health International LLC outside the submitted work. Dr Panageas reports stock ownership in Johnson & Johnson, Pfizer, Viking Therapeutics, and Catalyst Biotech outside the submitted work. Dr Kantoff reports personal fees from Bavarian Nordic Immunotherapeutics, GE Healthcare, Genentech/Roche, Janssen, Merck, OncoCell MDx, Progenity, SynDevRx, and Tarveda Therapeutics; other support from Cogent Biosciences and Placon; and personal fees and other support from Context Therapeutics LLC, Druggability Technologies Holdings, Mirati, Seer Biosciences, and XLink outside the submitted work. No other disclosures were reported.
Funding/Support: This work was supported by the Department of Defense office of the Congressionally Directed Medical Research Programs through the Peer Reviewed Medical Research Program Clinical Trial Award (W81XWH-15-1-0245). This work was also supported in part by a National Institutes of Health/National Cancer Institute Cancer Center grant (P30 CA008748).
Role of the Funder/Sponsor: The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Disclaimer: Opinions, interpretations, conclusions, and recommendations in this article are those of the authors and are not necessarily endorsed by the Department of Defense.
Data Sharing Statement: See Supplement 3.
Additional Contributions: We thank the patients who participated in this study, as well as the acupuncturists and research staff for their dedication to the research process. Compensation was not provided for any contributions.
J , Buscemi
J , Ferguson
MJ . The future of pain research, education, and treatment: a summary of the IOM report “Relieving pain in America: a blueprint for transforming prevention, care, education, and research”. Transl Behav Med
. 2012;2(1):6-8. doi:10.1007/s13142-012-0110-2PubMedGoogle ScholarCrossref
R , Baxter
J , Gallagher
et al. Building capacity for complementary and integrative medicine through a large, cross-agency, acupuncture training program: lessons learned from a military health system and veterans health administration joint initiative project. Mil Med
. 2018;183(11-12):e486-e493. doi:10.1093/milmed/usy028PubMedGoogle ScholarCrossref
KT , Baser
R , Romero
et al. Personalized electro-acupuncture versus auricular-acupuncture comparative effectiveness (PEACE): a protocol of a randomized controlled trial for chronic musculoskeletal pain in cancer survivors. Medicine (Baltimore)
. 2020;99(21):e20085. doi:10.1097/MD.0000000000020085PubMedGoogle Scholar
JJ , Farrar
JT , Armstrong
K , Donahue
A , Ngo
J , Bowman
MA . De qi: Chinese acupuncture patients’ experiences and beliefs regarding acupuncture needling sensation—an exploratory survey. Acupunct Med
. 2007;25(4):158-165. doi:10.1136/aim.25.4.158PubMedGoogle ScholarCrossref
CS , Ryan
KM . Pain assessment: global use of the Brief Pain Inventory. Ann Acad Med Singap
. 1994;23(2):129-138.PubMedGoogle Scholar
RD , Bjorner
JB , Revicki
DA , Spritzer
KL , Cella
D . Development of physical and mental health summary scores from the patient-reported outcomes measurement information system (PROMIS) global items. Qual Life Res
. 2009;18(7):873-880. doi:10.1007/s11136-009-9496-9PubMedGoogle ScholarCrossref
DA , Kawata
AK , Harnam
N , Chen
WH , Hays
RD , Cella
D . Predicting EuroQol (EQ-5D) scores from the patient-reported outcomes measurement information system (PROMIS) global items and domain item banks in a United States sample. Qual Life Res
. 2009;18(6):783-791. doi:10.1007/s11136-009-9489-8PubMedGoogle ScholarCrossref
PA , Taylor
R , Thielke
R , Payne
J , Gonzalez
N , Conde
JG . Research electronic data capture (REDCap)—a metadata-driven methodology and workflow process for providing translational research informatics support. J Biomed Inform
. 2009;42(2):377-381. doi:10.1016/j.jbi.2008.08.010PubMedGoogle ScholarCrossref
GF , Lu
K , Mogg
R , Mallick
M , Mehrotra
DV . Should baseline be a covariate or dependent variable in analyses of change from baseline in clinical trials? Stat Med
. 2009;28(20):2509-2530. doi:10.1002/sim.3639PubMedGoogle ScholarCrossref
DL , Unger
JM , Greenlee
et al. Effect of acupuncture vs sham acupuncture or waitlist control on joint pain related to aromatase inhibitors among women with early-stage breast cancer: a randomized clinical trial. JAMA
. 2018;320(2):167-176. doi:10.1001/jama.2018.8907PubMedGoogle ScholarCrossref