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COVID-19 in 2021—Continuing Uncertainty

Educational Objective
To identify the key insights or developments described in this article
1 Credit CME

More than a year has passed since the first confirmed case of SARS-CoV-2 infection in the US was reported on January 20, 2020. What followed was an unprecedented year with nearly 30 million documented infections and more than 500 000 excess deaths in the US due to SARS-CoV-2. Alongside this devastation is the successful development and deployment of multiple safe and effective vaccines.1

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Article Information

Corresponding Author: Carlos del Rio, MD, Emory University School of Medicine, 49 Jesse Hill Jr Dr, FOB, Room 201, Atlanta, GA 30303 (cdelrio@emory.edu).

Published Online: March 4, 2021. doi:10.1001/jama.2021.3760

Conflict of Interest Disclosures: Dr del Rio reports receiving grants from NIH/NIAID Emory Vaccine and Treatment Evaluation Unit. No other disclosures were reported.

References
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Creech  CB , Walker  SC , Samuels  RJ .  SARS-CoV-2 vaccines.   JAMA. Published online February 26, 2021. PubMedGoogle Scholar
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Dagan  N , Barda  N , Kepten  E ,  et al.  BNT162b2 mRNA Covid-19 vaccine in a nationwide mass vaccination setting.   N Engl J Med. Published online February 24, 2021. doi:10.1056/NEJMoa2101765 PubMedGoogle Scholar
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Salmon  DA , Dudley  MZ , Glanz  JM , Omer  SB .  Vaccine hesitancy: causes, consequences, and a call to action.   Am J Prev Med. 2015;49(6)(suppl 4):S391-S398. doi:10.1016/j.amepre.2015.06.009 PubMedGoogle ScholarCrossref
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Hamel  L , Kirzinger  A , Muňana  C , Brodie  M. KFF COVID-19 vaccine monitor: December 2020. Accessed February 25, 2021. https://www.kff.org/coronavirus-covid-19/report/kff-covid-19-vaccine-monitor-december-2020/
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CDC. Interim clinical considerations for use of mRNA COVID-19 vaccines currently authorized in the United States. Accessed February 24, 2021. https://www.cdc.gov/vaccines/covid-19/info-by-product/clinical-considerations.html
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Moore  JP , Offit  PA .  SARS-CoV-2 vaccines and the growing threat of viral variants.   JAMA. Published online January 28, 2021. doi:10.1001/jama.2021.1114PubMedGoogle Scholar
8.
Novavax COVID-19 vaccine demonstrates 89.3% efficacy in U.K. phase 3 trial. January 28, 2021. https://ir.novavax.com/news-releases/news-release-details/novavax-covid-19-vaccine-demonstrates-893-efficacy-uk-phase-3
9.
Iacobucci  G , Mahase  E .  Covid-19 vaccination: what’s the evidence for extending the dosing interval?   BMJ. 2021;372(n18):n18. doi:10.1136/bmj.n18 PubMedGoogle ScholarCrossref
10.
Krammer  F , Srivastava  K , the PARIS team, Simon  V .  Robust spike antibody responses and increased reactogenicity in seropositive individuals after a single dose of SARS-CoV-2 mRNA vaccine.   medRxiv. Preprint published online February 1, 2021. doi:10.1101/2021.01.29.21250653Google Scholar
AMA CME Accreditation Information

Credit Designation Statement: The American Medical Association designates this Journal-based CME activity activity for a maximum of 1.00  AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to:

  • 1.00 Medical Knowledge MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program;;
  • 1.00 Self-Assessment points in the American Board of Otolaryngology – Head and Neck Surgery’s (ABOHNS) Continuing Certification program;
  • 1.00 MOC points in the American Board of Pediatrics’ (ABP) Maintenance of Certification (MOC) program;
  • 1.00 Lifelong Learning points in the American Board of Pathology’s (ABPath) Continuing Certification program; and
  • 1.00 credit toward the CME [and Self-Assessment requirements] of the American Board of Surgery’s Continuous Certification program

It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting MOC credit.

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