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COVID-19 in 2021—Continuing Uncertainty

Educational Objective
To identify the key insights or developments described in this article
1 Credit CME

More than a year has passed since the first confirmed case of SARS-CoV-2 infection in the US was reported on January 20, 2020. What followed was an unprecedented year with nearly 30 million documented infections and more than 500 000 excess deaths in the US due to SARS-CoV-2. Alongside this devastation is the successful development and deployment of multiple safe and effective vaccines.1

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Article Information

Corresponding Author: Carlos del Rio, MD, Emory University School of Medicine, 49 Jesse Hill Jr Dr, FOB, Room 201, Atlanta, GA 30303 (cdelrio@emory.edu).

Published Online: March 4, 2021. doi:10.1001/jama.2021.3760

Conflict of Interest Disclosures: Dr del Rio reports receiving grants from NIH/NIAID Emory Vaccine and Treatment Evaluation Unit. No other disclosures were reported.

References
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CDC. Interim clinical considerations for use of mRNA COVID-19 vaccines currently authorized in the United States. Accessed February 24, 2021. https://www.cdc.gov/vaccines/covid-19/info-by-product/clinical-considerations.html
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Moore  JP , Offit  PA .  SARS-CoV-2 vaccines and the growing threat of viral variants.   JAMA. Published online January 28, 2021. doi:10.1001/jama.2021.1114PubMedGoogle Scholar
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Novavax COVID-19 vaccine demonstrates 89.3% efficacy in U.K. phase 3 trial. January 28, 2021. https://ir.novavax.com/news-releases/news-release-details/novavax-covid-19-vaccine-demonstrates-893-efficacy-uk-phase-3
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