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A 39-year-old female patient with alveolar rhabdomyosarcoma and bone metastases presented in April 2020 with lower back pain, which was aggravated while standing and walking. She reported no known trauma, and no motor or sensory deficits were noted during clinical examination. She had no fever.
After the initial sarcoma diagnosis in September 2018, the patient received 8 cycles of doxorubicin hydrochloride and ifosfamide along with regional hyperthermia, followed by good tumor response. The patient had a history of a pathological fracture of L4, which had been treated with radiotherapy and vertebroplasty in November 2019 and remained unchanged on imaging obtained in April 2020. The treatment regimen recently had been switched to gemcitabine hydrochloride and docetaxel in January 2020 following osseous progression during maintenance chemotherapy with trofosfamide, idarubicin hydrochloride, and etoposide.
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C. Radiation recall myositis
Radiation recall is a rare diagnosis in which inflammatory reactions are induced by chemotherapeutic agents in previously irradiated tissues. D’Angio et al1 were the first to describe this phenomenon in 1959. In pediatric and adult patients treated first with radiotherapy and then with intravenous administration of actinomycin D, development of erythema was observed and was sharply limited to prior irradiation fields in the course of actinomycin D treatment.
Since publication of the study by D’Angio et al,1 many cytotoxic agents have been identified as potential triggers for radiation recall events. Among the most frequent drugs associated with these events are anthracyclines and taxanes, such as docetaxel.2 In recent years, gemcitabine also was implicated in several cases.3 Although radiation recall was initially and most often reported to affect the skin, such reactions associated with use of gemcitabine predominantly seem to be associated with inflammation of internal tissues, especially muscles, triggering radiation recall myositis.4- 6
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Corresponding Author: Wolfgang G. Kunz, MD, Department of Radiology, University Hospital, LMU Munich, Marchioninistr 15, 81377 Munich, Germany (firstname.lastname@example.org).
Published Online: March 25, 2021. doi:10.1001/jamaoncol.2020.8080
Conflict of Interest Disclosures: None reported.
Additional Contributions: We thank the patient for granting permission to publish this information. We also thank Lars H. Lindner, MD; Nina-Sophie Schmidt-Hegemann, MD; and Marcus Unterrainer, MD, PhD, MHBA, all of LMU Munich, for their contributions in data collection and their thoughtful comments on the manuscript. They were not compensated for their contributions.
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