Corresponding Author: Xavier Monnet, MD, PhD, Service de Médecine Intensive-Réanimation, Hôpital de Bicêtre, 78, rue du Général Leclerc, 94 270 Le Kremlin-Bicêtre, France (xavier.monnet@aphp.fr).
Accepted for Publication: February 22, 2021.
Published Online: March 17, 2021. doi:10.1001/jama.2021.3331
Authors/Writing Committee for the COMEBAC Study Group Luc Morin, MD, MSc; Laurent Savale, MD, PhD; Tài Pham, MD, PhD; Romain Colle, MD, PhD; Samy Figueiredo, MD, PhD; Anatole Harrois, MD, PhD; Matthieu Gasnier, MD; Anne-Lise Lecoq, MD, PhD; Olivier Meyrignac, MD, PhD; Nicolas Noel, MD, PhD; Elodie Baudry, MD; Marie-France Bellin, MD; Antoine Beurnier, MD; Walid Choucha, MD; Emmanuelle Corruble, MD, PhD; Laurent Dortet, PharmD, PhD; Isabelle Hardy-Leger, MA; François Radiguer, MA; Sabine Sportouch, MA; Christiane Verny, MD; Benjamin Wyplosz, MD, PhD; Mohamad Zaidan, MD, PhD; Laurent Becquemont, MD, PhD; David Montani, MD, PhD; Xavier Monnet, MD, PhD.
Affiliations of Authors/Writing Committee for the COMEBAC Study Group: Université Paris-Saclay, AP-HP, Service de Réanimation Pédiatrique et Médecine Néonatale, Hôpital de Bicêtre, Santé de l'Enfant et de l'Adolescent, Le Kremlin-Bicêtre, France (Morin); Université Paris-Saclay, AP-HP, Service de Pneumologie et Soins Intensifs Respiratoires, DMU 5, Thorinno, Inserm UMR_S999, Hôpital de Bicêtre, Le Kremlin-Bicêtre, France (Savale, Montani); Université Paris-Saclay, AP-HP, Service de Médecine Intensive-Réanimation, Hôpital de Bicêtre, DMU 4 CORREVE Maladies du Cœur et des Vaisseaux, FHU Sepsis, Le Kremlin-Bicêtre, France (Pham, Sportouch, Monnet); Université Paris-Saclay, AP-HP, Service de Psychiatrie, Hôpital de Bicêtre, DMU 11 Psychiatrie, Santé Mentale, Addictologie et Nutrition, Équipe MOODS, INSERM U1178, CESP (Centre de Recherche en Epidémiologie et Santé des Populations), Le Kremlin-Bicêtre, France (Colle, Gasnier, Choucha, Corruble); Université Paris-Saclay, AP-HP, Service de Réanimation Chirurgicale, Hôpital de Bicêtre, DMU 12 Anesthésie, Réanimation, Douleur, Le Kremlin-Bicêtre, France (Figueiredo, Harrois, Radiguer); Université Paris-Saclay, AP-HP, Centre de Recherche Clinique Paris-Saclay, DMU 13 Santé Publique, Information Médicale, Appui à la Recherche Clinique, INSERM U1018, CESP, Le Kremlin-Bicêtre, France (Lecoq, Becquemont); Université Paris-Saclay, AP-HP, Service de Radiologie Diagnostique et Interventionnelle, Hôpital de Bicêtre, Le Kremlin-Bicêtre, France (Meyrignac, Bellin); Université Paris-Saclay, AP-HP, Service de Médecine Interne et Immunologie Clinique, Hôpital de Bicêtre, DMU 7 Endocrinologie-Immunités-Inflammations Cancer-Urgences, Le Kremlin-Bicêtre, France (Noel, Hardy-Leger); Université Paris-Saclay, AP-HP, Service de Gériatrie Aiguë, Hôpital de Bicêtre, DMU 1 Médecine Territoire Gériatrie, Le Kremlin-Bicêtre, France (Baudry, Verny); Université Paris-Saclay, AP-HP, Service de Physiologie et d'Explorations Fonctionnelles Respiratoires, Hôpital de Bicêtre, DMU 5 Thorinno, Inserm UMR_S999, Le Kremlin-Bicêtre, France (Beurnier); Université Paris-Saclay, AP-HP, Service de Microbiologie, Hôpital de Bicêtre, DMU 15 Biologie-Génétique-PUI, INSERM 1193, Le Kremlin-Bicêtre, France (Dortet); Université Paris-Saclay, AP-HP, Service des Maladies Infectieuses et Tropicales, Hôpital de Bicêtre, DMU 7 Endocrinologie-Immunités-Inflammations Cancer-Urgences, INSERM U1018, CESP, Le Kremlin-Bicêtre, France (Wyplosz); Université Paris-Saclay, AP-HP, Service de Néphrologie Transplantation, Hôpital de Bicêtre, DMU 4 CORREVE Maladies du Cœur et des Vaisseaux, Le Kremlin-Bicêtre, France (Zaidan).
Author Contributions: Dr Monnet had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Concept and design: Morin, Savale, Pham, Colle, Figueiredo, Harrois, Gasnier, Lecoq, Meyrignac, Noel, Baudry, Bellin, Beurnier, Corruble, Dortet, Hardy-Leger, Sportouch, Wyplosz, Zaidan, Becquemont, Montani, Monnet.
Acquisition, analysis, or interpretation of data: Morin, Savale, Pham, Colle, Figueiredo, Harrois, Gasnier, Lecoq, Meyrignac, Noel, Bellin, Beurnier, Choucha, Corruble, Dortet, Radiguer, Sportouch, Verny, Wyplosz, Zaidan, Becquemont, Montani, Monnet.
Drafting of the manuscript: Morin, Savale, Pham, Colle, Figueiredo, Harrois, Meyrignac, Noel, Baudry, Bellin, Beurnier, Corruble, Dortet, Hardy-Leger, Sportouch, Wyplosz, Zaidan, Becquemont, Montani, Monnet.
Critical revision of the manuscript for important intellectual content: Morin, Savale, Pham, Colle, Figueiredo, Harrois, Gasnier, Lecoq, Meyrignac, Noel, Baudry, Bellin, Beurnier, Choucha, Corruble, Dortet, Radiguer, Verny, Wyplosz, Zaidan, Becquemont, Montani, Monnet.
Statistical analysis: Morin, Pham, Colle, Figueiredo, Noel, Dortet, Radiguer, Wyplosz, Monnet.
Obtained funding: Savale, Baudry, Wyplosz, Becquemont, Monnet.
Administrative, technical, or material support: Morin, Pham, Figueiredo, Harrois, Lecoq, Baudry, Bellin, Beurnier, Sportouch, Wyplosz, Becquemont, Montani, Monnet.
Supervision: Morin, Savale, Pham, Figueiredo, Noel, Baudry, Choucha, Corruble, Dortet, Sportouch, Wyplosz, Zaidan, Becquemont, Montani, Monnet.
Other: Sportouch.
Conflict of Interest Disclosures: Dr Harrois reported personal fees from LFB Laboratory and Edwards, and fees from Mindray Fees to his institution, outside the submitted work. Dr Lecoq reported nonfinancial support from Pfizer SAS and from Sanofi Aventis France outside the submitted work. Dr Noel reported personal fees from MSD and from Biogen outside the submitted work. Dr Beurnier reported personal fees from Sanofi outside the submitted work. Dr Becquemont reported grants from Sanofi Genzyme for a presentation concerning Gaucher disease, and pharmacogenetics and drug interactions with Eliglustat outside the submitted work. Dr Montani reported personal fees from Actelion, GSK, Pfizer, MSD, Chiesi, Boehringer, and Incyte Biosciences France; grants from Bayer and MSD; and nonfinancial support from Acceleron, outside the submitted work. Dr Monnet reported personal fees from Getinge Pulsion Medical and Baxter outside the submitted work. No other disclosures were reported.
Funding/Support: This study was funded by Assistance Publique-Hôpitaux de Paris.
Role of the Funder/Sponsor: The funder was not involved in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication. The sponsor did not have the right to veto publication or to control the decision regarding to which journal the paper was submitted.
Data Sharing Statement: The data sets generated during the current study are available from the corresponding author on request.
Additional Contributions: We thank Thomas Piraino, RRT, FCST (Department of Anesthesia, Division of Critical Care, McMaster University), for English editing. He did not receive financial compensation for his contribution. We thank Jackie Abdel Nour, Younes Boujana, Marie Deloncle, Tatiana Fouasse, Nassim Hamidat, Mario Hindie, Yasmine Iftene, Jean-Vincent Laqua, Jules Madjarian, Dalil Sadki, and Sabrina Safer, all from Paris-Saclay Medical School, for their help in data collection. They received financial compensation for their contribution. We thank Cassandre Sainrose, Paris 8 University, for her help in data collection. She did not receive financial compensation for her contribution. We thank the patients who participated in this cohort, as well as the physicians, psychologists, nurses, care helpers, biologists, pharmacists, other allied health professionals, and the administrators of the Bicêtre Hospital.
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