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Clinical Decision Support

The COVID-GRAM Tool for Patients Hospitalized With COVID-19 in Europe

Educational Objective
To identify the key insights or developments described in this article

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JAMA Internal Medicine

April 5, 2021

Research Letter

Article Information and Disclosures

Óscar Moreno-Pérez, MD, PhD^1,2;

Mariano Andrés, MD, PhD^2,3;

José Manuel León-Ramirez, MD⁴;

et al

José Sánchez-Payá, MD, PhD, MPH⁵;

Vicente Boix, MD, PhD^6,7;

Joan Gil, MD, PhD⁴;

Esperanza Merino, MD, PhD⁶

Author Affiliations

¹Endocrinology and Nutrition Department, Alicante General University Hospital–Alicante Institute of Sanitary and Biomedical Research (ISABIAL), Alicante, Spain
²Clinical Medicine Department, Miguel Hernández University, Alicante, Spain
³Rheumatology Department, Alicante General University Hospital–Alicante Institute of Sanitary and Biomedical Research (ISABIAL), Alicante, Spain
⁴Pneumology Department, Alicante General University Hospital–Alicante Institute of Sanitary and Biomedical Research (ISABIAL), Alicante, Spain
⁵Preventive Department, Alicante General University Hospital–Alicante Institute of Sanitary and Biomedical Research (ISABIAL), Alicante, Spain
⁶Unit of Infectious Diseases, Alicante General University Hospital–Alicante Institute of Health and Biomedical Research (ISABIAL), Alicante, Spain
⁷Clinical Medicine Department, Miguel Hernández University, Elche, Spain

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Liang and colleagues¹ recently validated a clinical risk tool (the COVID-GRAM) to predict the development of critical COVID-19 illness—defined as admission to the intensive care unit (ICU), requiring invasive mechanical ventilation, or death—after hospitalization admission in a nationwide cohort in China. Risk scores, applied to 10 variables that were independent predictors of critical illness, were used to classify patients as having a low (0.7% probability), medium (7.3%), or high risk (59.3%) of developing a critical illness.

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Article Information

Accepted for Publication: January 30, 2021.

Published Online: April 5, 2021. doi:10.1001/jamainternmed.2021.0491

Corresponding Author: Óscar Moreno-Pérez, MD, PhD, Endocrinology and Nutrition Department, Alicante General University Hospital–Alicante Institute of Sanitary and Biomedical Research (ISABIAL), C/Pintor Baeza S/N, 03010 Alicante, Spain (omoreno@umh.es).

Author Contributions: Dr Moreno-Pérez had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.

Concept and design: Moreno-Pérez, Andrés, León-Ramirez, Sánchez-Payá, Boix, Merino.

Acquisition, analysis, or interpretation of data: Moreno-Pérez, Andrés, León-Ramirez, Sánchez-Payá, Gil, Merino.

Drafting of the manuscript: Moreno-Pérez, Andrés, León-Ramirez, Sánchez-Payá, Gil, Merino.

Critical revision of the manuscript for important intellectual content: All authors.

Statistical analysis: Moreno-Pérez, Andrés, Sánchez-Payá.

Supervision: León-Ramirez, Boix, Gil, Merino.

Conflict of Interest Disclosures: Dr Moreno-Pérez reported consulting and speaking fees from AstraZeneca, Boehringer Ingelheim, Lilly, Merck Sharp & Dohme, and Novo Nordisk, all outside the submitted work. No other disclosures were reported.

References

Liang W , Liang H , Ou L , et al; China Medical Treatment Expert Group for COVID-19. Development and validation of a clinical risk score to predict the occurrence of critical illness in hospitalized patients with COVID-19. JAMA Intern Med. 2020;180(8):1081-1089. doi:10.1001/jamainternmed.2020.2033 PubMed Google Scholar Crossref

Steinberg E , Balakrishna A , Habboushe J , Shawl A , Lee J . Calculated decisions: COVID-19 calculators during extreme resource-limited situations. Emerg Med Pract. 2020;22(4)(suppl):CD1-CD5.PubMed Google Scholar

Metlay JP , Waterer GW , Long AC , et al. Diagnosis and treatment of adults with community-acquired pneumonia: an official clinical practice guideline of the American Thoracic Society and Infectious Diseases Society of America. Am J Respir Crit Care Med. 2019;200(7):e45-e67. doi:10.1164/rccm.201908-1581ST PubMed Google Scholar Crossref

The COVID-GRAM Tool for Patients Hospitalized With COVID-19 in Europe

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