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Incidence of 30-Day Venous Thromboembolism in Adults Tested for SARS-CoV-2 Infection in an Integrated Health Care System in Northern California

Educational Objective
To identify the key insights or developments described in this article
1 Credit CME

Hospitalization for COVID-19 is associated with high rates of venous thromboembolism (VTE).1 Whether SARS-CoV-2 infection affects the risk of VTE outside of the hospital setting remains poorly understood. We report on the 30-day incidence of outpatient and hospital-associated VTE following SARS-CoV-2 testing among adult members of the Kaiser Permanente Northern California health plan.

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Article Information

Accepted for Publication: February 1, 2021.

Published Online: April 5, 2021. doi:10.1001/jamainternmed.2021.0488

Corresponding Author: Nareg H. Roubinian, MD, Division of Research, Kaiser Permanente Northern California, 2000 Broadway, Oakland, CA 94612 (nareg.n.roubinian@kp.org).

Author Contributions: Dr Roubinian and Ms Dusendang had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.

Concept and design: All authors.

Acquisition, analysis, or interpretation of data: Roubinian, Dusendang, Mark, Vinson, Schmittdiel, Pai.

Drafting of the manuscript: Roubinian, Dusendang, Liu.

Critical revision of the manuscript for important intellectual content: Roubinian, Dusendang, Mark, Vinson, Schmittdiel, Pai.

Statistical analysis: Roubinian, Dusendang, Schmittdiel.

Obtained funding: Roubinian.

Administrative, technical, or material support: Liu, Schmittdiel, Pai.

Supervision: Roubinian, Schmittdiel.

Conflict of Interest Disclosures: Dr Roubinian reported grants from the National Institutes of Health and the National Heart, Lung, and Blood Institute (R01HL126130) during the conduct of the study. Dr Liu reported grants from the National Institute of General Medical Sciences (R35GM128672) during the conduct of the study. No other disclosures were reported.

Funding/Support: Funding for this work was provided by The Permanente Medical Group Delivery Science and Applied Research Program.

Role of the Funder/Sponsor: The funder had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.

References
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Moores  LK , Tritschler  T , Brosnahan  S ,  et al.  Prevention, diagnosis, and treatment of VTE in patients with coronavirus disease 2019: CHEST guideline and expert panel report.   Chest. 2020;158(3):1143-1163. doi:10.1016/j.chest.2020.05.559PubMedGoogle ScholarCrossref
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Gerotziafas  GT , Catalano  M , Colgan  MP ,  et al; Scientific Reviewer Committee.  Guidance for the management of patients with vascular disease or cardiovascular risk factors and COVID-19: position paper from VAS-European Independent Foundation in Angiology/Vascular Medicine.   Thromb Haemost. 2020;120(12):1597-1628. doi:10.1055/s-0040-1715798PubMedGoogle ScholarCrossref
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