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Death and disease in adult patients from the COVID-19 pandemic continue unabated across the world well into 2021,1 and why children have escaped severe disease from this virus2 remains one of the most intriguing gaps in our understanding of the immune response to this virus. Of equal imperative, what insights can be gained via a deeper understanding as to why some children do become critically ill from COVID-19 and the more recently described multisystem inflammatory syndrome in children (MIS-C)? Unlocking the key immunologic mechanisms driving these outcomes will likely initially emerge from meticulous epidemiologic studies that describe the few children who do get very ill from this disease.
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CME Disclosure Statement: Unless noted, all individuals in control of content reported no relevant financial relationships. If applicable, all relevant financial relationships have been mitigated.
Corresponding Author: Jennifer A. Blumenthal, MD, Critical Care Medicine and Infectious Diseases, Division of Critical Care Medicine, Boston Children’s Hospital, 300 Longwood Ave, Mail Stop Bader 634, Boston, MA 02115 (firstname.lastname@example.org).
Published Online: April 6, 2021. doi:10.1001/jamapediatrics.2021.0638
Conflict of Interest Disclosures: None reported.
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