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S-Gene Target Failure as a Marker of Variant B.1.1.7 Among SARS-CoV-2 Isolates in the Greater Toronto Area, December 2020 to March 2021

Educational Objective
To identify the key insights or developments described in this article
1 Credit CME

A novel variant of SARS-CoV-2, B.1.1.7, originally discovered in the UK, is rapidly overtaking wild-type SARS-CoV-2 globally,1 due to a substantial transmission advantage. This variant is estimated to be 40% to 80% more transmissible2 and 35% more lethal3 than the wild-type virus.

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CME Disclosure Statement: Unless noted, all individuals in control of content reported no relevant financial relationships. If applicable, all relevant financial relationships have been mitigated.

Article Information

Corresponding Author: Kevin A. Brown, PhD, Public Health Ontario, 480 University Ave, Ste 300, Toronto, ON M5G1V2, Canada (kevin.brown@utoronto.ca).

Accepted for Publication: March 26, 2021.

Published Online: April 8, 2021. doi:10.1001/jama.2021.5607

Author Contributions: Drs Brown and Goneau had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.

Concept and design: Brown, Goneau.

Acquisition, analysis, or interpretation of data: All authors.

Drafting of the manuscript: Brown, Goneau.

Critical revision of the manuscript for important intellectual content: All authors.

Statistical analysis: Brown.

Administrative, technical, or material support: Brown, Gubbay, Hopkins, Buchan, Goneau.

Overseeing sample testing including whole genome sequencing and analysis: Patel.

Conflict of Interest Disclosures: None reported.

AMA CME Accreditation Information

Credit Designation Statement: The American Medical Association designates this Journal-based CME activity activity for a maximum of 1.00  AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to:

  • 1.00 Medical Knowledge MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program;;
  • 1.00 Self-Assessment points in the American Board of Otolaryngology – Head and Neck Surgery’s (ABOHNS) Continuing Certification program;
  • 1.00 MOC points in the American Board of Pediatrics’ (ABP) Maintenance of Certification (MOC) program;
  • 1.00 Lifelong Learning points in the American Board of Pathology’s (ABPath) Continuing Certification program; and
  • 1.00 credit toward the CME of the American Board of Surgery’s Continuous Certification program

It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting MOC credit.

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