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Spike Antibody Levels of Nursing Home Residents With or Without Prior COVID-19 3 Weeks After a Single BNT162b2 Vaccine Dose

Educational Objective
To identify the key insights or developments described in this article
1 Credit CME

Recent studies have suggested that, to reach immunity, immunocompetent SARS-CoV-2 seropositive adults may only require 1 dose rather than 2 doses of a messenger RNA vaccine1,2; however, these studies did not include older adults. Older adults living in nursing homes are at higher risk for severe COVID-19, and the immune response to the vaccine may differ from that of younger, healthier adults.

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Article Information

Corresponding Author: Hubert Blain, MD, PhD, Pôle de Gérontologie, CHU de Montpellier, 39 Avenue Charles Flahault, 34295 Montpellier Cedex 5, France (h-blain@chu-montpellier.fr).

Accepted for Publication: April 2, 2021.

Published Online: April 15, 2021. doi:10.1001/jama.2021.6042

Author Contributions: Dr Blain had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.

Concept and design: Blain, Tuaillon, Miot.

Acquisition, analysis, or interpretation of data: Blain, Tuaillon, Gamon, Pisoni, Picot, Bousquet.

Drafting of the manuscript: Blain, Tuaillon.

Critical revision of the manuscript for important intellectual content: All authors.

Statistical analysis: Gamon, Pisoni, Picot.

Administrative, technical, or material support: Blain, Tuaillon, Pisoni.

Supervision: Blain, Tuaillon, Bousquet.

Conflict of Interest Disclosures: None reported.

Additional Contributions: We thank Anna Bedbrook and Fabienne Portejoie (Department of Dermatology and Allergy, Universitätsmedizin, Berlin), Eva Pons (Master Métiers de l’Enseignement, de l’Education et de la Formation, Éducation Nationale Française, Lyon), and Samuel Alizon, PhD (Montpellier University), for editorial assistance. We also thank Joy Martin (Department of Geriatrics, Montpellier University Hospital and Secours Infirmiers) and Véronique Vera and Florence Biblocque (Montpellier University Hospital admission office) for material support. None of these contributors received any compensation for their help in carrying out the study. In addition, we thank the residents and staff members of the nursing homes involved in the study.

References
1.
Wise  J .  Covid-19: people who have had infection might only need one dose of mRNA vaccine.   BMJ. 2021;372(n308):n308. doi:10.1136/bmj.n308PubMedGoogle ScholarCrossref
2.
Saadat  S , Tehrani  ZR , Logue  J ,  et al.  Binding and neutralization antibody titers after a single vaccine dose in health care workers previously infected with SARS-CoV-2.   JAMA. Published online March 1, 2021.doi:10.1001/jama.2021.3341PubMedGoogle Scholar
3.
Blain  H , Gamon  L , Tuaillon  E ,  et al.  Atypical symptoms, SARS-CoV-2 test results and immunisation rates in 456 residents from eight nursing homes facing a COVID-19 outbreak.   Age Ageing. Published online February 23, 2021. doi:10.1093/ageing/afab050 Google Scholar
4.
Blain  H , Rolland  Y , Schols  JMGA ,  et al.  August 2020 interim EuGMS guidance to prepare European long-term care facilities for COVID-19.   Eur Geriatr Med. 2020;11(6):899-913. doi:10.1007/s41999-020-00405-zPubMedGoogle ScholarCrossref
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