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Recent studies have suggested that, to reach immunity, immunocompetent SARS-CoV-2 seropositive adults may only require 1 dose rather than 2 doses of a messenger RNA vaccine1,2; however, these studies did not include older adults. Older adults living in nursing homes are at higher risk for severe COVID-19, and the immune response to the vaccine may differ from that of younger, healthier adults.
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Corresponding Author: Hubert Blain, MD, PhD, Pôle de Gérontologie, CHU de Montpellier, 39 Avenue Charles Flahault, 34295 Montpellier Cedex 5, France (email@example.com).
Accepted for Publication: April 2, 2021.
Published Online: April 15, 2021. doi:10.1001/jama.2021.6042
Author Contributions: Dr Blain had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Concept and design: Blain, Tuaillon, Miot.
Acquisition, analysis, or interpretation of data: Blain, Tuaillon, Gamon, Pisoni, Picot, Bousquet.
Drafting of the manuscript: Blain, Tuaillon.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Gamon, Pisoni, Picot.
Administrative, technical, or material support: Blain, Tuaillon, Pisoni.
Supervision: Blain, Tuaillon, Bousquet.
Conflict of Interest Disclosures: None reported.
Additional Contributions: We thank Anna Bedbrook and Fabienne Portejoie (Department of Dermatology and Allergy, Universitätsmedizin, Berlin), Eva Pons (Master Métiers de l’Enseignement, de l’Education et de la Formation, Éducation Nationale Française, Lyon), and Samuel Alizon, PhD (Montpellier University), for editorial assistance. We also thank Joy Martin (Department of Geriatrics, Montpellier University Hospital and Secours Infirmiers) and Véronique Vera and Florence Biblocque (Montpellier University Hospital admission office) for material support. None of these contributors received any compensation for their help in carrying out the study. In addition, we thank the residents and staff members of the nursing homes involved in the study.
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