Accepted for Publication: March 15, 2021.
Published: May 11, 2021. doi:10.1001/jamanetworkopen.2021.12131
Open Access: This is an open access article distributed under the terms of the CC-BY License. © 2021 Chou SHY et al. JAMA Network Open.
Corresponding Author: Sherry H-Y. Chou, MD, MSc , Department of Critical Care Medicine, University of Pittsburgh School of Medicine, 3550 Terrace St, Scaife Hall 646, Pittsburgh, PA 15261 (hsc36@pitt.edu).
Author Contributions: Dr Chou had full access to all of the data in the Global Consortium Study of Neurological Manifestations of COVID-19 cohort, and Dr Helbok had full access to all of the data in the European Academy of Neurology Neuro-COVID Registry. They take responsibility for the integrity of the data and the accuracy of the data analysis.
Concept and design: Chou, Beghi, Helbok, Moro, Altamirano, Mainali, Bassetti, Suarez, McNett.
Acquisition, analysis, or interpretation of data: Chou, Beghi, Helbok, Moro, Sampson, Altamirano, Mainali, McNett.
Drafting of the manuscript: Chou, Beghi, Helbok, Sampson, Mainali, Suarez, McNett.
Critical revision of the manuscript for important intellectual content: Chou, Beghi, Helbok, Moro, Altamirano, Mainali, Bassetti, McNett.
Statistical analysis: Chou, Beghi, Sampson, Altamirano, McNett.
Obtained funding: Chou.
Administrative, technical, or material support: Chou, Helbok, Altamirano, McNett.
Supervision: Chou, Beghi, Helbok, Moro, Bassetti, Suarez, McNett.
Conflict of Interest Disclosures: Dr Beghi reported receiving grants from the European Academy of Neurology during the conduct of the study; receiving grants from the Italian Ministry of Health, the American ALS Association, and Swedish Orphan Biuvitrun and receiving personal fees from Arvelle Therapeutics outside the submitted work. Dr Moro reported receiving personal fees from Medtronic and Newronika and receiving grants from Ipsen outside the submitted work. Dr Mainali reported receiving grants from the Center for Clinical and Translational Science at the Ohio State University, sponsored by a National Center for Advancing Translational Sciences Award, outside the submitted work. No other disclosures were reported.
Funding/Support: This publication was supported by the National Institutes of Health, National Center for Advancing Translational Sciences through grant UL1 TR001857 to the University of Pittsburgh and Dr Chou, the National Institute of Health through grant R21NS113037 to Dr Chou, and the University of Pittsburgh Dean’s Faculty Advancement Award to Dr Chou. Data collection for the European registry was supported by the European Academy of Neurology.
Role of the Funder/Sponsor: The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Group Members: The GCS-NeuroCOVID Consortium and the ENERGY Consortium members appear in Supplement 2.
Additional Information: The study protocol and case report forms have been previously published and are currently available.24,27,28 Deidentified data may be available at the conclusion of all studies of either consortia by request for specific scientific investigations and meta-analyses, at the discretion of the data coordinating centers for each respective consortium and in accordance with applicable privacy laws and data use agreements.
13.Zubair
AS , McAlpine
LS , Gardin
T , Farhadian
S , Kuruvilla
DE , Spudich
S . Neuropathogenesis and neurologic manifestations of the coronaviruses in the age of coronavirus disease 2019: a review.
JAMA Neurol. 2020;77(8):1018-1027. doi:
10.1001/jamaneurol.2020.2065
PubMedGoogle ScholarCrossref 24.Beghi
E , Helbok
R , Crean
M ,
et al; EAN Neuro-COVID Task Force. The European Academy of Neurology COVID-19 registry (ENERGY): an international instrument for surveillance of neurological complications in patients with COVID-19.
Eur J Neurol. 2020. doi:
10.1111/ene.14652PubMedGoogle Scholar 29.Beghi
E , Helbok
R , Crean
M ,
et al; EAN Neuro-COVID Task Force. The European Academy of Neurology COVID-19 registry (ENERGY): an international instrument for surveillance of neurological complications in patients with COVID-19.
Eur J Neurol. Published online November 21, 2020.
PubMedGoogle Scholar 30.Moro
E , Priori
A , Beghi
E ,
et al; EAN core COVID-19 Task Force. The international European Academy of Neurology survey on neurological symptoms in patients with COVID-19 infection.
Eur J Neurol. 2020;27(9):1727-1737. doi:
10.1111/ene.14407
PubMedGoogle ScholarCrossref 39.Tong
JY , Wong
A , Zhu
D , Fastenberg
JH , Tham
T . The prevalence of olfactory and gustatory dysfunction in COVID-19 patients: a systematic review and meta-analysis.
Otolaryngol Head Neck Surg. 2020;163(1):3-11. doi:
10.1177/0194599820926473PubMedGoogle ScholarCrossref 43.Aggarwal
G , Lippi
G , Michael Henry
B . Cerebrovascular disease is associated with an increased disease severity in patients with coronavirus disease 2019 (COVID-19): a pooled analysis of published literature.
Int J Stroke. 2020;15(4):385-389. doi:
10.1177/1747493020921664
PubMedGoogle ScholarCrossref