Want to take quizzes and track your credits?
A man in his mid-50s with a medical history significant for pulmonary embolism 10 years prior (previously receiving anticoagulation therapy) presented to the emergency department with 10 days of progressively worsening, sharp, nonradiating chest pain. The pain was present at rest, 7 of 10 in severity, and worse with inspiration. He experienced concomitant exertional shortness of breath, dry cough, and lightheadedness. His cardiac history was otherwise unremarkable. Family history was notable for breast cancer in his mother and his sister, but no known inherited hypercoagulable disorders. In the emergency department, his vital signs were as follows: temperature 37.0 °C, blood pressure 130/76 mm Hg, heart rate 97/min, respiratory rate 16/min, and oxygen saturation of 95% on room air. Physical examination results were unremarkable, with no cardiac murmurs, rubs, pulmonary crackles, jugular venous distention, or lower extremity edema. Laboratory test results were remarkable for an elevated D-dimer level, an elevated C-reactive protein level and erythrocyte sedimentation rate, and a mildly elevated pro-BNP level, but normal levels of troponin and procalcitonin. An electrocardiogram showed normal sinus rhythm with evidence of right heart strain, and a computed tomography angiogram of the chest demonstrated an occlusive pulmonary embolism of the left main pulmonary artery and several peripheral consolidations in the left lower lung field consistent with infarction. The patient started anticoagulation therapy with intravenous heparin. A subsequent echocardiogram revealed bowing of the interventricular septum into the left ventricle and a very large (6.6 × 4.1-cm), mobile, nonhomogeneous, pedunculated mass straddling the tricuspid valve and moving between the right atrium and right ventricle (Figure 1 and Video).
Please finish quiz first before checking answer.
Read the answer below and download your certificate.
Read the discussion below and retake the quiz.
Right atrial myxoma with partial myxomatous embolism to the pulmonary artery
D. Perform a surgical resection of the mass
Primary cardiac tumors are rare, occurring in less than 0.1% of patients.1 Of these, myxomas are the most common primary tumors. Originating from primitive connective tissues cells, myxomas are benign masses composed of cells within a mucopolysaccharide stroma.1,2 They usually occur sporadically but can be inherited and are more frequently found in middle-aged adults, with a greater predilection for women.3 The left atrium is the most common intracardiac location of the tumor noted in 75% to 80% of patients, but it can also be found in the right atrium (10%-20%) or in the right or left ventricle (5%-10%).4
Sign in to take quiz and track your certificates
JN Learning™ is the home for CME and MOC from the JAMA Network. Search by specialty or US state and earn AMA PRA Category 1 CME Credit™ from articles, audio, Clinical Challenges and more. Learn more about CME/MOC
CME Disclosure Statement: Unless noted, all individuals in control of content reported no relevant financial relationships. If applicable, all relevant financial relationships have been mitigated.
Published Online: May 12, 2021. doi:10.1001/jamacardio.2021.0954
Correction: This article was corrected on May 26, 2021, to fix the original magnification listed in the caption to Figure 2.
Corresponding Author: Prakriti Gaba, MD, Division of Cardiovascular Medicine, Brigham and Women’s Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115 (email@example.com).
Conflict of Interest Disclosures: None reported.
Additional Contributions: We thank the patient for granting permission to publish this information.
You currently have no searches saved.
You currently have no courses saved.