Accepted for Publication: March 24, 2021.
Published: May 19, 2021. doi:10.1001/jamanetworkopen.2021.10323
Open Access: This is an open access article distributed under the terms of the CC-BY License. © 2021 Davogustto GE et al. JAMA Network Open.
Corresponding Author: Giovanni E. Davogustto, MD, Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, 2220 Pierce Ave, 383 Preston Research Bldg, Nashville, TN 37232-6300 (giovanni.e.davogustto@vumc.org).
Author Contributions: Dr Davogustto had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Concept and design: Davogustto, Clark, Hardison, Halasa, Wells.
Acquisition, analysis, or interpretation of data: All authors.
Drafting of the manuscript: Davogustto, Clark, Hardison.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Davogustto.
Administrative, technical, or material support: Davogustto, Clark, Hardison, Yanis, Lowery.
Supervision: Wells.
Conflict of Interest Disclosures: Dr Halasa reported receiving grants from Sanofi and Quidel outside the submitted work. No other disclosures were reported.
Funding/Support: Vanderbilt University’s Research Derivative and Research Electronic Data Capture (REDCap) resources are supported by Clinical and Translational Science Award UL1 TR002243 from the National Center for Advancing Translational Sciences. Research reported in this article was supported in part by award T32HL007411 from the National Heart, Lung, and Blood Institute of the National Institutes of Health (Dr Clark).
Role of the Funder/Sponsor: The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Disclaimer: The content and views expressed in this article are those of the authors and do not necessarily represent official views of the National Center for Advancing Translational Sciences or the National Institutes of Health.
Additional Contributions: We thank Josh F. Peterson, MD, MPH, Lisa Bastarache, MS, and others in the Department of Biomedical Informatics of Vanderbilt University Medical Center (VUMC) for stimulating discussions on the initial design of the study and for creating and making readily available a COVID-19 data registry from electronic health records into VUMC’s Research Derivative. We also thank Dan M. Roden, MD (VUMC), for stimulating discussions on study design and his critical review of the manuscript. None of these individuals were compensated for their contributions.
1.Feldstein
LR , Rose
EB , Horwitz
SM ,
et al; Overcoming COVID-19 Investigators; CDC COVID-19 Response Team. Multisystem inflammatory syndrome in U.S. children and adolescents.
N Engl J Med. 2020;383(4):334-346. doi:
10.1056/NEJMoa2021680
PubMedGoogle ScholarCrossref 2.Dufort
EM , Koumans
EH , Chow
EJ ,
et al; New York State and Centers for Disease Control and Prevention Multisystem Inflammatory Syndrome in Children Investigation Team. Multisystem inflammatory syndrome in children in New York State.
N Engl J Med. 2020;383(4):347-358. doi:
10.1056/NEJMoa2021756
PubMedGoogle ScholarCrossref 4.Morris
SB , Schwartz
NG , Patel
P ,
et al. Case Series of multisystem inflammatory syndrome in adults associated with SARS-CoV-2 infection—United Kingdom and United States, March-August 2020.
MMWR Morb Mortal Wkly Rep. 2020;69(40):1450-1456. doi:
10.15585/mmwr.mm6940e1
PubMedGoogle ScholarCrossref