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Medication Use Patterns in Hospitalized Patients With COVID-19 in California During the Pandemic

Educational Objective
To identify the key insights or developments described in this article
1 Credit CME

The novel SARS-CoV-2 virus has caused more than 118 million cases of COVID-19 and more than 2.6 million deaths worldwide.1 To evaluate the use of potential therapeutic options—including dexamethasone, remdesivir, enoxaparin, heparin, colchicine, hydrocortisone, tocilizumab, azithromycin, hydroxychloroquine, and medication classes of angiotensin-2 converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs)2—we measured daily and overall use percentages over the course of 2020 for hospitalized patients.

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CME Disclosure Statement: Unless noted, all individuals in control of content reported no relevant financial relationships. If applicable, all relevant financial relationships have been mitigated.

Article Information

Accepted for Publication: March 27, 2021.

Published: May 21, 2021. doi:10.1001/jamanetworkopen.2021.10775

Open Access: This is an open access article distributed under the terms of the CC-BY License. © 2021 Watanabe JH et al. JAMA Network Open.

Corresponding Author: Jonathan H. Watanabe, PharmD, PhD, Associate Dean of Assessment and Quality, Professor of Clinical Pharmacy, Department of Clinical Pharmacy Practice, UC Irvine School of Pharmacy & Pharmaceutical Sciences, 101 Theory, Ste 100, Irvine, CA 92697 (jonathan.watanabe@uci.edu).

Author Contributions: Dr Watanabe had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.

Concept and design: Watanabe, Kwon, Nan, Abeles, Mehta.

Acquisition, analysis, or interpretation of data: All authors.

Drafting of the manuscript: Watanabe, Jia.

Critical revision of the manuscript for important intellectual content: Watanabe, Kwon, Nan, Abeles, Mehta.

Statistical analysis: Watanabe, Kwon, Nan, Jia.

Administrative, technical, or material support: Watanabe, Mehta.

Supervision: Watanabe, Nan, Mehta.

Conflict of Interest Disclosures: None reported.

References
1.
COVID-19 Map. Johns Hopkins Coronavirus Resource Center. Accessed March 12, 2021. https://coronavirus.jhu.edu/map.html
2.
COVID-19 Treatment Guidelines—Therapeutic Management. National Institutes of Health. Accessed March 8, 2021. https://www.covid19treatmentguidelines.nih.gov/therapeutic-management/
3.
Moores  LK , Tritschler  T , Brosnahan  S ,  et al.  Prevention, diagnosis, and treatment of VTE in patients with coronavirus disease 2019: CHEST guideline and expert panel report.   Chest. 2020;158(3):1143-1163. doi:10.1016/j.chest.2020.05.559PubMedGoogle ScholarCrossref
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US Food and Drug Administration. Coronavirus (COVID-19) Update: FDA Issues Emergency Use Authorization for Potential COVID-19 Treatment. Press release. Published May 1, 2020. Accessed April 16, 2021. https://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-fda-issues-emergency-use-authorization-potential-covid-19-treatment
5.
Gautret  P , Lagier  J-C , Parola  P ,  et al.  Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial.   Int J Antimicrob Agents. 2020;56(1):105949. doi:10.1016/j.ijantimicag.2020.105949PubMedGoogle Scholar
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Group  TRC .  Effect of Hydroxychloroquine in Hospitalized Patients with Covid-19.   N Engl J Med. 2021;383(21):2030-2040. doi:10.1056/NEJMoa2022926Google Scholar
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