Update on the Diagnosis and Treatment of POEMS (Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal Gammopathy, and Skin Changes) Syndrome: A Review | Dermatology | JN Learning | AMA Ed Hub [Skip to Content]
[Skip to Content Landing]

Update on the Diagnosis and Treatment of POEMS (Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal Gammopathy, and Skin Changes) SyndromeA Review

Educational Objective
To learn the diagnosis and treatment strategies for POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes) syndrome.
1 Credit CME

Importance  POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes) syndrome is a rare plasma cell disorder characterized by demyelinating peripheral neuropathy and clonal plasma cell proliferation. Clinical manifestations are believed to be associated with a surge of inflammatory and angiogenic mediators, including interleukins and vascular endothelial growth factor (VEGF), elicited by clonal and polyclonal plasma cells. The clinical manifestations of POEMS syndrome can be debilitating; therefore, early diagnosis is essential. This review discusses several aspects of POEMS syndrome and includes the most recently published findings, with a special emphasis on diagnosis and treatment strategies.

Observations  POEMS syndrome may be underdiagnosed because of its rarity, and it can be mistaken for chronic inflammatory demyelinating polyneuropathy; this misdiagnosis may lead to delayed therapy and progressive worsening of symptoms, especially neuropathy. Therefore, in addition to measurement of the VEGF level, patients with a monoclonal protein detected in blood and/or urine and neuropathy should be evaluated for POEMS syndrome with use of imaging to assess whether sclerotic bone lesions, effusions, and organomegaly are present. Clinical trials are scant, and treatment is largely based on small case series in which plasma cell–directed therapies, borrowed from the myeloma armamentarium, were used. High-dose melphalan and autologous hematopoietic cell transplantation may be offered to eligible patients. Lenalidomide and dexamethasone can be prescribed for patients who are ineligible for transplants. The main goals of therapy are to attain complete hematologic and VEGF responses and to reduce symptoms, although it may take up to 3 years for neurologic deficits to be ameliorated.

Conclusions and Relevance  POEMS syndrome should be considered in the differential diagnosis for patients who have peripheral neuropathy and paraproteinemia among other multisystem manifestations. The syndrome can be debilitating if not recognized early in its course; thus, appropriate diagnosis and treatment are important for optimal clinical outcomes.

Sign in to take quiz and track your certificates

Buy This Activity

JN Learning™ is the home for CME and MOC from the JAMA Network. Search by specialty or US state and earn AMA PRA Category 1 CME Credit™ from articles, audio, Clinical Challenges and more. Learn more about CME/MOC

CME Disclosure Statement: Unless noted, all individuals in control of content reported no relevant financial relationships. If applicable, all relevant financial relationships have been mitigated.

Article Information

Accepted for Publication: February 12, 2021.

Published Online: June 3, 2021. doi:10.1001/jamaoncol.2021.0586

Corresponding Author: Jack Khouri, MD, Department of Hematology and Medical Oncology, Taussig Cancer Center, Cleveland Clinic, Floor CA6, 10201 Carnegie Ave, Cleveland, OH 44195 (khourij@ccf.org).

Author Contributions: Dr Khouri had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.

Concept and design: Khouri, Wong.

Acquisition, analysis, or interpretation of data: All authors.

Drafting of the manuscript: Khouri.

Critical revision of the manuscript for important intellectual content: All authors.

Administrative, technical, or material support: Nakashima.

Supervision: Khouri, Wong.

Conflict of Interest Disclosures: Dr Khouri reported receiving honoraria from Sanofi Genzyme and OncLive. Dr Nakashima reported receiving an honorarium from QualWorld and research funding from CellaVision. Dr Wong reported receiving consulting fees from Amgen, honoraria from Sanofi Genzyme, and research funding from Genentech, Bristol Myers Squibb, Fortis, Janssen, and GlaxoSmithKline.

D’Souza  A , Hayman  SR , Buadi  F ,  et al.  The utility of plasma vascular endothelial growth factor levels in the diagnosis and follow-up of patients with POEMS syndrome.   Blood. 2011;118(17):4663-4665. doi:10.1182/blood-2011-06-362392 PubMedGoogle ScholarCrossref
Dispenzieri  A .  POEMS syndrome: 2019 update on diagnosis, risk-stratification, and management.   Am J Hematol. 2019;94(7):812-827. doi:10.1002/ajh.25495 PubMedGoogle Scholar
Nasu  S , Misawa  S , Sekiguchi  Y ,  et al.  Different neurological and physiological profiles in POEMS syndrome and chronic inflammatory demyelinating polyneuropathy.   J Neurol Neurosurg Psychiatry. 2012;83(5):476-479. doi:10.1136/jnnp-2011-301706 PubMedGoogle ScholarCrossref
Watanabe  O , Maruyama  I , Arimura  K ,  et al.  Overproduction of vascular endothelial growth factor/vascular permeability factor is causative in Crow-Fukase (POEMS) syndrome.   Muscle Nerve. 1998;21(11):1390-1397. doi:10.1002/(SICI)1097-4598(199811)21:11<1390::AID-MUS5>3.0.CO;2-4 PubMedGoogle ScholarCrossref
Koga  H , Tokunaga  Y , Hisamoto  T ,  et al.  Ratio of serum vascular endothelial growth factor to platelet count correlates with disease activity in a patient with POEMS syndrome.   Eur J Intern Med. 2002;13(1):70-74. doi:10.1016/S0953-6205(01)00199-6 PubMedGoogle ScholarCrossref
Yamada  Y , Sawai  S , Misawa  S ,  et al.  Multiple angiogenetic factors are upregulated in POEMS syndrome.   Ann Hematol. 2013;92(2):245-248. doi:10.1007/s00277-012-1583-2 PubMedGoogle ScholarCrossref
Gherardi  RK , Bélec  L , Soubrier  M ,  et al.  Overproduction of proinflammatory cytokines imbalanced by their antagonists in POEMS syndrome.   Blood. 1996;87(4):1458-1465. doi:10.1182/blood.V87.4.1458.bloodjournal8741458 PubMedGoogle ScholarCrossref
Wang  C , Huang  XF , Cai  QQ ,  et al.  Remarkable expression of vascular endothelial growth factor in bone marrow plasma cells of patients with POEMS syndrome.   Leuk Res. 2016;50:78-84. doi:10.1016/j.leukres.2016.09.017 PubMedGoogle ScholarCrossref
Jaccard  A .  POEMS syndrome: therapeutic options.   Hematol Oncol Clin North Am. 2018;32(1):141-151. doi:10.1016/j.hoc.2017.09.011 PubMedGoogle ScholarCrossref
Misawa  S , Sato  Y , Katayama  K ,  et al.  Vascular endothelial growth factor as a predictive marker for POEMS syndrome treatment response: retrospective cohort study.   BMJ Open. 2015;5(11):e009157. doi:10.1136/bmjopen-2015-009157 PubMedGoogle Scholar
Michizono  K , Umehara  F , Hashiguchi  T ,  et al.  Circulating levels of MMP-1, −2, −3, −9, and TIMP-1 are increased in POEMS syndrome.   Neurology. 2001;56(6):807-810. doi:10.1212/WNL.56.6.807 PubMedGoogle ScholarCrossref
Soubrier  M , Dubost  JJ , Serre  AF ,  et al.  Growth factors in POEMS syndrome: evidence for a marked increase in circulating vascular endothelial growth factor.   Arthritis Rheum. 1997;40(4):786-787. doi:10.1002/art.1780400430 PubMedGoogle ScholarCrossref
Kanai  K , Sawai  S , Sogawa  K ,  et al.  Markedly upregulated serum interleukin-12 as a novel biomarker in POEMS syndrome.   Neurology. 2012;79(6):575-582. doi:10.1212/WNL.0b013e318263c42b PubMedGoogle ScholarCrossref
Merlini  G , Stone  MJ .  Dangerous small B-cell clones.   Blood. 2006;108(8):2520-2530. doi:10.1182/blood-2006-03-001164 PubMedGoogle ScholarCrossref
Bender  S , Javaugue  V , Saintamand  A ,  et al.  Immunoglobulin variable domain high-throughput sequencing reveals specific novel mutational patterns in POEMS syndrome.   Blood. 2020;135(20):1750-1758. doi:10.1182/blood.2019004197 PubMedGoogle ScholarCrossref
Kourelis  TV , Jevremovic  D , Jessen  E ,  et al.  Mass cytometry identifies expansion of double positive and exhausted T cell subsets in the tumour microenvironment of patients with POEMS syndrome.   Br J Haematol. 2020;190(1):79-83. doi:10.1111/bjh.16522 PubMedGoogle ScholarCrossref
Caers  J .  Mass cytometry in POEMS (polyneuropathy, organomegaly, endocrinopathy, M-protein, skin changes) syndrome: looking for a needle in a haystack.   Br J Haematol. 2020;190(1):16-17. doi:10.1111/bjh.16554 PubMedGoogle ScholarCrossref
Chen  J , Gao  XM , Zhao  H ,  et al.  A highly heterogeneous mutational pattern in POEMS syndrome.   Leukemia. 2020;136:19. doi:10.1038/s41375-020-01101-4PubMedGoogle Scholar
Mauermann  ML .  The peripheral neuropathies of POEMS syndrome and Castleman disease.   Hematol Oncol Clin North Am. 2018;32(1):153-163. doi:10.1016/j.hoc.2017.09.012 PubMedGoogle ScholarCrossref
Koike  H , Iijima  M , Mori  K ,  et al.  Neuropathic pain correlates with myelinated fibre loss and cytokine profile in POEMS syndrome.   J Neurol Neurosurg Psychiatry. 2008;79(10):1171-1179. doi:10.1136/jnnp.2007.135681 PubMedGoogle ScholarCrossref
Keddie  S , Lunn  MP .  POEMS syndrome.   Curr Opin Neurol. 2018;31(5):551-558. doi:10.1097/WCO.0000000000000610 PubMedGoogle ScholarCrossref
Nakanishi  T , Sobue  I , Toyokura  Y ,  et al.  The Crow-Fukase syndrome: a study of 102 cases in Japan.   Neurology. 1984;34(6):712-720. doi:10.1212/WNL.34.6.712 PubMedGoogle ScholarCrossref
Dispenzieri  A , Kourelis  T , Buadi  F .  POEMS syndrome: diagnosis and investigative work-up.   Hematol Oncol Clin North Am. 2018;32(1):119-139. doi:10.1016/j.hoc.2017.09.010 PubMedGoogle ScholarCrossref
Gandhi  GY , Basu  R , Dispenzieri  A , Basu  A , Montori  VM , Brennan  MD .  Endocrinopathy in POEMS syndrome: the Mayo Clinic experience.   Mayo Clin Proc. 2007;82(7):836-842. doi:10.4065/82.7.836 PubMedGoogle ScholarCrossref
Miest  RYN , Comfere  NI , Dispenzieri  A , Lohse  CM , el-Azhary  RA .  Cutaneous manifestations in patients with POEMS syndrome.   Int J Dermatol. 2013;52(11):1349-1356. doi:10.1111/j.1365-4632.2012.05648.x PubMedGoogle ScholarCrossref
Kaushik  M , Pulido  JS , Abreu  R , Amselem  L , Dispenzieri  A .  Ocular findings in patients with polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes syndrome.   Ophthalmology. 2011;118(4):778-782. doi:10.1016/j.ophtha.2010.08.013 PubMedGoogle ScholarCrossref
Stankowski-Drengler  T , Gertz  MA , Katzmann  JA ,  et al.  Serum immunoglobulin free light chain measurements and heavy chain isotype usage provide insight into disease biology in patients with POEMS syndrome.   Am J Hematol. 2010;85(6):431-434. doi:10.1002/ajh.21707 PubMedGoogle Scholar
Wang  C , Su  W , Zhang  W ,  et al.  Serum immunoglobulin free light chain and heavy/light chain measurements in POEMS syndrome.   Ann Hematol. 2014;93(7):1201-1206. doi:10.1007/s00277-014-2019-y PubMedGoogle ScholarCrossref
Dao  LN , Hanson  CA , Dispenzieri  A , Morice  WG , Kurtin  PJ , Hoyer  JD .  Bone marrow histopathology in POEMS syndrome: a distinctive combination of plasma cell, lymphoid, and myeloid findings in 87 patients.   Blood. 2011;117(24):6438-6444. doi:10.1182/blood-2010-11-316935 PubMedGoogle ScholarCrossref
Li  J , Zhou  DB , Huang  Z ,  et al.  Clinical characteristics and long-term outcome of patients with POEMS syndrome in China.   Ann Hematol. 2011;90(7):819-826. doi:10.1007/s00277-010-1149-0 PubMedGoogle ScholarCrossref
Tokashiki  T , Hashiguchi  T , Arimura  K , Eiraku  N , Maruyama  I , Osame  M .  Predictive value of serial platelet count and VEGF determination for the management of DIC in the Crow-Fukase (POEMS) syndrome.   Intern Med. 2003;42(12):1240-1243. doi:10.2169/internalmedicine.42.1240 PubMedGoogle ScholarCrossref
Pihan  M , Keddie  S , D’Sa  S ,  et al.  Raised VEGF: high sensitivity and specificity in the diagnosis of POEMS syndrome.   Neurol Neuroimmunol Neuroinflamm. 2018;5(5):e486. doi:10.1212/NXI.0000000000000486 PubMedGoogle Scholar
Sayar  Z , Weatherill  A , Keddie  S ,  et al.  High rates of venous and arterial thrombotic events in patients with POEMS syndrome: results from the UCLH (UK) POEMS Registry.   Blood Adv. 2020;4(10):2139-2142. doi:10.1182/bloodadvances.2020001492 PubMedGoogle ScholarCrossref
Dupont  SA , Dispenzieri  A , Mauermann  ML , Rabinstein  AA , Brown  RD  Jr .  Cerebral infarction in POEMS syndrome: incidence, risk factors, and imaging characteristics.   Neurology. 2009;73(16):1308-1312. doi:10.1212/WNL.0b013e3181bd136b PubMedGoogle ScholarCrossref
Li  J , Tian  Z , Zheng  HY ,  et al.  Pulmonary hypertension in POEMS syndrome.   Haematologica. 2013;98(3):393-398. doi:10.3324/haematol.2012.073031 PubMedGoogle ScholarCrossref
He  T , Tian  Z , Liu  YT , Li  J , Zhou  DB , Fang  Q .  Evaluating heart function in patients with POEMS syndrome.   Echocardiography. 2019;36(11):1997-2003. doi:10.1111/echo.14516 PubMedGoogle ScholarCrossref
Albertí  MA , Martinez-Yélamos  S , Fernandez  A ,  et al.  18F-FDG PET/CT in the evaluation of POEMS syndrome.   Eur J Radiol. 2010;76(2):180-182. doi:10.1016/j.ejrad.2009.06.004 PubMedGoogle ScholarCrossref
Kuwabara  S , Dispenzieri  A , Arimura  K , Misawa  S , Nakaseko  C .  Treatment for POEMS (polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes) syndrome.   Cochrane Database Syst Rev. 2012;(6):CD006828. doi:10.1002/14651858.CD006828.pub3 PubMedGoogle Scholar
Kourelis  TV , Buadi  FK , Kumar  SK ,  et al.  Long-term outcome of patients with POEMS syndrome: an update of the Mayo Clinic experience.   Am J Hematol. 2016;91(6):585-589. doi:10.1002/ajh.24356 PubMedGoogle ScholarCrossref
Kourelis  TV , Buadi  FK , Gertz  MA ,  et al.  Risk factors for and outcomes of patients with POEMS syndrome who experience progression after first-line treatment.   Leukemia. 2016;30(5):1079-1085. doi:10.1038/leu.2015.344 PubMedGoogle ScholarCrossref
Humeniuk  MS , Gertz  MA , Lacy  MQ ,  et al.  Outcomes of patients with POEMS syndrome treated initially with radiation.   Blood. 2013;122(1):68-73. doi:10.1182/blood-2013-03-487025 PubMedGoogle ScholarCrossref
Suh  YG , Kim  YS , Suh  CO ,  et al.  The role of radiotherapy in the management of POEMS syndrome.   Radiat Oncol. 2014;9:265. doi:10.1186/s13014-014-0265-8 PubMedGoogle ScholarCrossref
D’Souza  A , Lacy  M , Gertz  M ,  et al.  Long-term outcomes after autologous stem cell transplantation for patients with POEMS syndrome (osteosclerotic myeloma): a single-center experience.   Blood. 2012;120(1):56-62. doi:10.1182/blood-2012-04-423178 PubMedGoogle ScholarCrossref
Cook  G , Iacobelli  S , van Biezen  A ,  et al.  High-dose therapy and autologous stem cell transplantation in patients with POEMS syndrome: a retrospective study of the Plasma Cell Disorder sub-committee of the Chronic Malignancy Working Party of the European Society for Blood & Marrow Transplantation.   Haematologica. 2017;102(1):160-167. doi:10.3324/haematol.2016.148460 PubMedGoogle ScholarCrossref
Kawajiri-Manako  C , Sakaida  E , Ohwada  C ,  et al.  Efficacy and long-term outcomes of autologous stem cell transplantation in POEMS Syndrome: a nationwide survey in Japan.   Biol Blood Marrow Transplant. 2018;24(6):1180-1186. doi:10.1016/j.bbmt.2018.01.026PubMedGoogle ScholarCrossref
Tomkins  O , Keddie  S , Lunn  MP , D’Sa  S .  High-dose therapy and autologous transplantation for POEMS syndrome: effective, but how to optimise?   Br J Haematol. 2019;186(6):e178-e181. doi:10.1111/bjh.16057 PubMedGoogle ScholarCrossref
Jaccard  A , Royer  B , Bordessoule  D , Brouet  JC , Fermand  JP .  High-dose therapy and autologous blood stem cell transplantation in POEMS syndrome.   Blood. 2002;99(8):3057-3059. doi:10.1182/blood.V99.8.3057 PubMedGoogle ScholarCrossref
Dispenzieri  A , Lacy  MQ , Hayman  SR ,  et al.  Peripheral blood stem cell transplant for POEMS syndrome is associated with high rates of engraftment syndrome.   Eur J Haematol. 2008;80(5):397-406. doi:10.1111/j.1600-0609.2008.01037.x PubMedGoogle ScholarCrossref
Jang  IY , Yoon  DH , Kim  S ,  et al.  Advanced POEMS syndrome treated with high-dose melphalan followed by autologous blood stem cell transplantation: a single-center experience.   Blood Res. 2014;49(1):42-48. doi:10.5045/br.2014.49.1.42 PubMedGoogle ScholarCrossref
Li  J , Duan  MH , Wang  C ,  et al.  Impact of pretransplant induction therapy on autologous stem cell transplantation for patients with newly diagnosed POEMS syndrome.   Leukemia. 2017;31(6):1375-1381. doi:10.1038/leu.2017.27 PubMedGoogle ScholarCrossref
Muto  T , Ohwada  C , Takaishi  K ,  et al.  Safety and efficacy of granulocyte colony-stimulating factor monotherapy for peripheral blood stem cell collection in POEMS syndrome.   Biol Blood Marrow Transplant. 2017;23(2):361-363. doi:10.1016/j.bbmt.2016.10.024 PubMedGoogle ScholarCrossref
Autore  F , Piccirillo  N , Nozza  A ,  et al.  Peripheral blood hemopoietic stem cell mobilization regimens in POEMS syndrome: a retrospective study at 2 hematologic Italian centers.   Biol Blood Marrow Transplant. 2019;25(12):2514-2516. doi:10.1016/j.bbmt.2019.08.011 PubMedGoogle ScholarCrossref
Nozza  A , Terenghi  F , Gallia  F ,  et al.  Lenalidomide and dexamethasone in patients with POEMS syndrome: results of a prospective, open-label trial.   Br J Haematol. 2017;179(5):748-755. doi:10.1111/bjh.14966 PubMedGoogle ScholarCrossref
Royer  B , Merlusca  L , Abraham  J ,  et al.  Efficacy of lenalidomide in POEMS syndrome: a retrospective study of 20 patients.   Am J Hematol. 2013;88(3):207-212. doi:10.1002/ajh.23374 PubMedGoogle ScholarCrossref
Jaccard  A , Magy  L .  Thalidomide and POEMS syndrome: a cautious step forward.   Lancet Neurol. 2016;15(11):1104-1105. doi:10.1016/S1474-4422(16)30176-4 PubMedGoogle ScholarCrossref
Zagouri  F , Kastritis  E , Gavriatopoulou  M ,  et al.  Lenalidomide in patients with POEMS syndrome: a systematic review and pooled analysis.   Leuk Lymphoma. 2014;55(9):2018-2023. doi:10.3109/10428194.2013.869329 PubMedGoogle ScholarCrossref
Li  J , Huang  XF , Cai  QQ ,  et al.  A prospective phase II study of low dose lenalidomide plus dexamethasone in patients with newly diagnosed polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome.   Am J Hematol. 2018;93(6):803-809. doi:10.1002/ajh.25100 PubMedGoogle ScholarCrossref
He  H , Fu  W , Du  J , Jiang  H , Hou  J .  Successful treatment of newly diagnosed POEMS syndrome with reduced-dose bortezomib based regimen.   Br J Haematol. 2018;181(1):126-128. doi:10.1111/bjh.14497 PubMedGoogle ScholarCrossref
Warsame  R , Kohut  IE , Dispenzieri  A .  Successful use of cyclophosphamide, bortezomib, and dexamethasone to treat a case of relapsed POEMS.   Eur J Haematol. 2012;88(6):549-550. doi:10.1111/j.1600-0609.2012.01780.x PubMedGoogle ScholarCrossref
Dispenzieri  A , Mauermann  M , LaPlant  B ,  et al.  A prospective pilot study of ixazomib, lenalidomide, and dexamethasone for patients with newly diagnosed or relapsed/refractory POEMS syndrome.   Blood. 2019;134:1846. doi:10.1182/blood-2019-127366Google ScholarCrossref
Zhao  H , Huang  XF , Gao  XM ,  et al.  What is the best first-line treatment for POEMS syndrome: autologous transplantation, melphalan and dexamethasone, or lenalidomide and dexamethasone?   Leukemia. 2019;33(4):1023-1029. doi:10.1038/s41375-019-0391-2 PubMedGoogle ScholarCrossref
Khan  M , Stone  K , van Rhee  F .  Daratumumab for POEMS syndrome.   Mayo Clin Proc. 2018;93(4):542-544. doi:10.1016/j.mayocp.2018.02.001 PubMedGoogle ScholarCrossref
Gavriatopoulou  M , Ntanasis-Stathopoulos  I , Fotiou  D ,  et al.  Upfront daratumumab with lenalidomide and dexamethasone for POEMS syndrome.   Hemasphere. 2020;4(3):e381. doi:10.1097/HS9.0000000000000381 PubMedGoogle Scholar
A phase II trial for the treatment of poems syndrome with daratumumab. ClinicalTrials.gov identifier NCT04396496. Updated March 2, 2021. Accessed September 2, 2020. https://clinicaltrials.gov/ct2/show/NCT04396496
Sekiguchi  Y , Misawa  S , Shibuya  K ,  et al.  Ambiguous effects of anti-VEGF monoclonal antibody (bevacizumab) for POEMS syndrome.   J Neurol Neurosurg Psychiatry. 2013;84(12):1346-1348. doi:10.1136/jnnp-2012-304874 PubMedGoogle ScholarCrossref
Straume  O , Bergheim  J , Ernst  P .  Bevacizumab therapy for POEMS syndrome.   Blood. 2006;107(12):4972-4973. doi:10.1182/blood-2005-12-5045 PubMedGoogle ScholarCrossref
Schwartz  J , Winters  JL , Padmanabhan  A ,  et al.  Guidelines on the use of therapeutic apheresis in clinical practice-evidence-based approach from the Writing Committee of the American Society for Apheresis: the sixth special issue.   J Clin Apher. 2013;28(3):145-284. doi:10.1002/jca.21276 PubMedGoogle ScholarCrossref
Want full access to the AMA Ed Hub?
After you sign up for AMA Membership, make sure you sign in or create a Physician account with the AMA in order to access all learning activities on the AMA Ed Hub
Buy this activity
Want full access to the AMA Ed Hub?
After you sign up for AMA Membership, make sure you sign in or create a Physician account with the AMA in order to access all learning activities on the AMA Ed Hub
Buy this activity
With a personal account, you can:
  • Access free activities and track your credits
  • Personalize content alerts
  • Customize your interests
  • Fully personalize your learning experience
Education Center Collection Sign In Modal Right

Name Your Search

Save Search
With a personal account, you can:
  • Access free activities and track your credits
  • Personalize content alerts
  • Customize your interests
  • Fully personalize your learning experience

Lookup An Activity



My Saved Searches

You currently have no searches saved.


My Saved Courses

You currently have no courses saved.

With a personal account, you can:
  • Access free activities and track your credits
  • Personalize content alerts
  • Customize your interests
  • Fully personalize your learning experience
Education Center Collection Sign In Modal Right