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Association of COVID-19 mRNA Vaccine With Ipsilateral Axillary Lymph Node Reactivity on Imaging

Educational Objective
To identify the key insights or developments described in this article
1 Credit CME

Intramuscular coronavirus 2019 (COVID-19) vaccinations could induce ipsilateral axillary lymph node reactivity that may be falsely attributed to malignant abnormality, prompting unwarranted interventions, or it may be falsely attributed to vaccination rather than cancer, potentially delaying cancer care. We aimed to investigate Moderna and Pfizer COVID-19 vaccine-related nodal reactivity on 18F-flurodeoxyglocose (FDG) positron emission tomographic (PET)/computed tomographic (CT) scans.

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Article Information

Accepted for Publication: April 14, 2021.

Published Online: June 10, 2021. doi:10.1001/jamaoncol.2021.1794

Corresponding Author: Mehmet Emin Adin, MD, 20 York St, New Haven, CT 06510 (Emin.adin@gmail.com).

Author Contributions: Drs Adin and Pucar had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. Authors are guarantors of integrity of the data and manuscript.

Concept and design: All authors.

Acquisition, analysis, or interpretation of data: All authors.

Drafting of the manuscript: Adin, Pucar.

Critical revision of the manuscript for important intellectual content: All authors.

Statistical analysis: Adin, Kulon, Pucar.

Administrative, technical, or material support: Adin, Isufi, Pucar.

Supervision: All authors.

Conflict of Interest Disclosures: Dr Kulon is an individual shareholder of pharmaceutical companies including Pfizer, Moderna, and Merck. No other conflicts are reported.

Additional Contributions: The authors thank Dr Hadyn Williams (Department of Radiology & Imaging, Nuclear Medicine, Medical College of Georgia, Augusta University) for his editorial work and insightful suggestions, Dr Yulei Pang (Southern Connecticut State University, Department of Mathematics) for her help in statistical analyses, and Dr Slobodon Pucar (private practice Neuropsychiatrist from Belgrade, Serbia) and Dr Richard Bronen (Department of Radiology and Biomedical Imaging, Yale School of Medicine) for their helpful discussions on the matter. They were not compensated.

References
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