Infection by the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), the cause of COVID-19, has been associated with numerous other medical complications aside from the known respiratory effects. Specifically, it is recognized that COVID-19 predisposes patients to thrombotic events in both the arterial and venous circulations. As a result, guidelines from several medical organizations recommend the use of prophylactic anticoagulation in patients with COVID-19.1 Nonetheless, these guidelines rely on expert opinion–level recommendations, as firm data are lacking. Over time, our knowledge on the use of anticoagulation has been expanding, initially from case series, followed by systemwide reports and international registries. Numerous randomized trials are ongoing. Despite this, a systematic review published in October 20202 found insufficient evidence to determine risks and benefits of use of prophylactic anticoagulation in patients with COVID-19. It is in this landscape that the current study was performed.
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Published: June 11, 2021. doi:10.1001/jamanetworkopen.2021.12403
Open Access: This is an open access article distributed under the terms of the CC-BY License. © 2021 Dicks AB et al. JAMA Network Open.
Corresponding Author: Ido Weinberg, MD, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114 (firstname.lastname@example.org).
Conflict of Interest Disclosures: Dr Weinberg reported receiving consulting fees from Magneto Thrombectomy Solutions outside the submitted work. No other disclosures were reported.
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