The consequences of the SARS-CoV-2 pandemic have been far-reaching, particularly among health care personnel (HCP) and within health care settings. HCP have been directly affected, sustaining occupationally acquired COVID-19 infections, and indirectly through a substantial alteration in health care delivery. With the advent of highly effective and safe SARS-CoV-2 vaccines, case rates and hospitalization rates are declining, and the promise of a return to some semblance of pre–COVID-19 health care is growing. Recently, several medical centers have announced a requirement for SARS-CoV-2 vaccination of all HCP (allowing for medical and religious exemptions), and the impending licensure of the mRNA SARS-CoV-2 vaccines (following the previous Emergency Use Authorization [EUA]) will move many other centers to consider a similar policy. A recent outbreak in a skilled nursing facility attributed to an unvaccinated HCP member clearly illustrates the risk unvaccinated HCP can pose to their patients and other HCP.1