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Clinical Outcomes for Patients With Anosmia 1 Year After COVID-19 Diagnosis

Educational Objective
To identify the key insights or developments described in this article
1 Credit CME

Since the pandemic was declared in early 2020, COVID-19–related anosmia quickly emerged as a telltale sign of infection.1,2 However, the time course and reversibility of COVID-19–related olfactory disorders, which may persist and negatively affect patients’ lives, require further study. To clarify the clinical course and prognosis, we followed a cohort of patients with COVID-19–related anosmia for 1 year and performed repeated olfactory function evaluations for a subset of patients.

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Article Information

Accepted for Publication: April 28, 2021.

Published: June 24, 2021. doi:10.1001/jamanetworkopen.2021.15352

Open Access: This is an open access article distributed under the terms of the CC-BY License. © 2021 Renaud M et al. JAMA Network Open.

Corresponding Author: Marion Renaud, MD, Otorhinolaryngology Department, University Hospitals of Strasbourg, 1 Ave Moliere, 67200 Strasbourg, France (marion.renaud@chru-strasbourg.fr).

Author Contributions: Drs Renaud and Venkatasamy had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.

Concept and design: Renaud, Debry, Venkatasamy.

Acquisition, analysis, or interpretation of data: Renaud, Thibault, Le Normand, Mcdonald, Gallix, Venkatasamy.

Drafting of the manuscript: Renaud, Venkatasamy.

Critical revision of the manuscript for important intellectual content: All authors.

Statistical analysis: Renaud, Venkatasamy.

Obtained funding: Venkatasamy.

Administrative, technical, or material support: Renaud, Thibault, Le Normand, Gallix.

Supervision: Renaud, Gallix, Debry, Venkatasamy.

Conflict of Interest Disclosures: None reported.

Funding/Support: This work was supported by French state funds managed within the Plan Investissements d’Avenir and by the Agence Nationale de la Recherche (grant No. ANR-10-IAHU-02).

Role of the Funder/Sponsor: The specific role of the funding organization was interpretation of data, review and approval of the manuscript, and decision to submit the manuscript for publication. The funder had no role in the design and conduct of the study; collection, management, and analysis of data; and preparation of the manuscript.

References
1.
Renaud  M , Leon  A , Trau  G ,  et al.  Acute smell and taste loss in outpatients: all infected with SARS-CoV-2?   Rhinology. 2020;58(4):406-409. doi:10.4193/Rhin20.199PubMedGoogle Scholar
2.
Struyf  T , Deeks  JJ , Dinnes  J ,  et al; Cochrane COVID-19 Diagnostic Test Accuracy Group.  Signs and symptoms to determine if a patient presenting in primary care or hospital outpatient settings has COVID-19 disease.   Cochrane Database Syst Rev. 2020;7(7):CD013665. doi:10.1002/14651858.CD013665PubMedGoogle Scholar
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Rumeau  C , Nguyen  DT , Jankowski  R .  How to assess olfactory performance with the Sniffin’ Sticks test(®).   Eur Ann Otorhinolaryngol Head Neck Dis. 2016;133(3):203-206. doi:10.1016/j.anorl.2015.08.004PubMedGoogle ScholarCrossref
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Lechien  JR , Chiesa-Estomba  CM , Beckers  E ,  et al.  Prevalence and 6-month recovery of olfactory dysfunction: a multicentre study of 1363 COVID-19 patients.   J Intern Med. Published online January 5, 2021. doi:10.1111/joim.13209PubMedGoogle Scholar
5.
Lechien  JR , Cabaraux  P , Chiesa-Estomba  CM ,  et al.  Objective olfactory evaluation of self-reported loss of smell in a case series of 86 COVID-19 patients.   Head Neck. 2020;42(7):1583-1590. doi:10.1002/hed.26279PubMedGoogle ScholarCrossref
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Hummel  T , Lötsch  J .  Prognostic factors of olfactory dysfunction.   Arch Otolaryngol Head Neck Surg. 2010;136(4):347-351. doi:10.1001/archoto.2010.27PubMedGoogle ScholarCrossref
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