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Utility of Mass SARS-CoV-2 Testing of Asymptomatic Patients Before Ambulatory and Inpatient Preplanned Procedures Requiring Moderate Sedation or General Anesthesia

Educational Objective
To identify the key insights or developments described in this article
1 Credit CME

Systematic management of procedures during the COVID-19 crisis is a priority to (1) detect and care appropriately for patients with COVID-19, (2) prevent outbreaks, and (3) safely maintain routine health care activities. SARS-CoV-2 presents unique challenges, as an estimated 50% of infections occur through asymptomatic transmission, and clinical screening may miss contagious patients.1,2 These factors complicate settings where aerosol-generating procedures (AGPs) are performed, potentially exposing health care personnel (HCP) to SARS-CoV-2 transmission. Furthermore, patients with COVID-19 have increased risks of postprocedural complications, and current guidelines suggest that testing asymptomatic patients prior to preplanned procedures may help to mitigate these risks.3 We describe our mass preprocedure SARS-CoV-2 nucleic acid amplification testing (NAAT) during a period of high community transmission.4

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Article Information

Accepted for Publication: April 19, 2021.

Published: June 25, 2021. doi:10.1001/jamanetworkopen.2021.14526

Open Access: This is an open access article distributed under the terms of the CC-BY License. © 2021 Roberts SC et al. JAMA Network Open.

Corresponding Author: Scott C. Roberts, MD, MS, Department of Internal Medicine, Yale School of Medicine, 20 York St, Hunter 527, New Haven, CT 06510 (scott.c.roberts@yale.edu).

Author Contributions: Drs Roberts and Pettker had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.

Concept and design: All authors.

Acquisition, analysis, or interpretation of data: Roberts, Peaper, Pettker.

Drafting of the manuscript: Roberts, Peaper, Pettker.

Critical revision of the manuscript for important intellectual content: All authors.

Statistical analysis: Roberts, Peaper.

Administrative, technical, or material support: Sussman.

Supervision: Peaper, Sussman, Martinello, Pettker.

Conflict of Interest Disclosures: Dr Peaper reported having equity options in Tangen Biosciences outside the submitted work. No other disclosures were reported.

References
1.
Johansson  MA , Quandelacy  TM , Kada  S ,  et al.  SARS-CoV-2 transmission from people without COVID-19 symptoms.   JAMA Netw Open. 2021;4(1):e2035057. doi:10.1001/jamanetworkopen.2020.35057PubMedGoogle Scholar
2.
Gudbjartsson  DF , Helgason  A , Jonsson  H ,  et al.  Spread of SARS-CoV-2 in the Icelandic population.   N Engl J Med. 2020;382(24):2302-2315. doi:10.1056/NEJMoa2006100PubMedGoogle ScholarCrossref
3.
Hanson  KE , Caliendo  AM , Arias  CA ,  et al. IDSA guidelines on the diagnosis of COVID-19: molecular diagnostic testing. Infectious Diseases Society of America. December 23, 2020. Accessed April 7, 2021. https://www.idsociety.org/practice-guideline/covid-19-guideline-diagnostics/
4.
Covidestim. Connecticut. Accessed January 21, 2021. https://covidestim.org/us/CT
5.
Ogrinc  G , Armstrong  GE , Dolansky  MA , Singh  MK , Davies  L .  SQUIRE-EDU (Standards for Quality Improvement Reporting Excellence in Education): publication guidelines for educational improvement.   Acad Med. 2019;94(10):1461-1470. doi:10.1097/ACM.0000000000002750PubMedGoogle ScholarCrossref
6.
Huang  JT , Ran  RX , Lv  ZH ,  et al.  Chronological changes of viral shedding in adult inpatients with COVID-19 in Wuhan, China.   Clin Infect Dis. 2020;71(16):2158-2166. doi:10.1093/cid/ciaa631PubMedGoogle ScholarCrossref
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