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Sperm Parameters Before and After COVID-19 mRNA Vaccination

Educational Objective
To identify the key insights or developments described in this article

Two mRNA vaccines, BNT162b2 (Pfizer-BioNTech) and mRNA-1273 (Moderna), received Emergency Use Authorization from the US Food and Drug Administration. Despite high efficacy and few adverse events found in clinical trials, only 56% of individuals in the US reported wanting to receive the vaccine.1 One of the reasons for vaccine hesitancy is the potential negative effect on fertility.2 Because reproductive toxicity was not evaluated in the clinical trials and SARS-CoV-2 has been associated with decreases in sperm parameters,3 we assessed sperm parameters before and after mRNA vaccine administration.

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Article Information

Corresponding Author: Ranjith Ramasamy, MD, Department of Urology, University of Miami Miller School of Medicine, 1120 NW 14th St, 15th Fl, Miami, FL 33136 (ramasamy@miami.edu).

Accepted for Publication: June 1, 2021.

Published Online: June 17, 2021. doi:10.1001/jama.2021.9976

Author Contributions: Dr Ramasamy and Mr Gonzalez had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.

Concept and design: Gonzalez, Nassau, Ory, Ramasamy.

Acquisition, analysis, or interpretation of data: Gonzalez, Nassau, Khodamoradi, Ibrahim, Blachman-Braun.

Drafting of the manuscript: Gonzalez, Nassau, Khodamoradi, Blachman-Braun, Ory.

Critical revision of the manuscript for important intellectual content: Gonzalez, Nassau, Ibrahim, Blachman-Braun, Ory, Ramasamy.

Statistical analysis: Blachman-Braun, Ramasamy.

Administrative, technical, or material support: Gonzalez, Nassau, Khodamoradi, Ibrahim.

Supervision: Nassau, Ibrahim, Ory, Ramasamy.

Conflict of Interest Disclosures: None reported.

Additional Contributions: We thank Iakov Efimenko, BSc, Justin Dubin, MD, and Manuel Molina, MD (all with University of Miami Department of Urology), for assistance with recruitment and institutional review board preparation, as well as Ali Tourchi, MD (University of Arkansas for Medical Sciences Department of Urology), for developing the concept of the study. None were compensated for their contributions.

References
1.
Szilagyi  PGTK , Thomas  K , Shah  MD ,  et al.  National trends in the US public’s likelihood of getting a COVID-19 vaccine: April 1 to December 8, 2020.   JAMA. 2020;325(4):396-398. doi:10.1001/jama.2020.26419PubMedGoogle ScholarCrossref
2.
Berry  SD , Johnson  KS , Myles  L ,  et al.  Lessons learned from frontline skilled nursing facility staff regarding COVID-19 vaccine hesitancy.   J Am Geriatr Soc. 2021;69(5):1140-1146. doi:10.1111/jgs.17136PubMedGoogle ScholarCrossref
3.
Best  JC , Kuchakulla  M , Khodamoradi  K ,  et al.  Evaluation of SARS-CoV-2 in human semen and effect on total sperm number: a prospective observational study.   World J Mens Health. 2021;39(e12).PubMedGoogle Scholar
4.
Cooper  TG , Noonan  E , von Eckardstein  S ,  et al.  World Health Organization reference values for human semen characteristics.   Hum Reprod Update. 2010;16(3):231-245. doi:10.1093/humupd/dmp048PubMedGoogle ScholarCrossref
5.
Keel  BA .  Within- and between-subject variation in semen parameters in infertile men and normal semen donors.   Fertil Steril. 2006;85(1):128-134. doi:10.1016/j.fertnstert.2005.06.048PubMedGoogle ScholarCrossref
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